{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:08:00Z","timestamp":1792631280817,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Triple\u2010negative breast cancer (TNBC) exhibits heightened aggressiveness compared with other breast cancer (BC) subtypes, with earlier relapse, a higher risk of distant metastasis, and a worse prognosis. Transcription factors play a pivotal role in various cancers. Here, we found that factor forkhead box M1 (FOXM1) expression was significantly higher in TNBC than in other BC subtypes and normal tissues. Combining the findings of Gene Ontology (GO) enrichment analysis and a series of experiments, we found that knockdown of the\n                    <jats:italic>FOXM1<\/jats:italic>\n                    gene attenuated the ability of TNBC cells to proliferate and metastasize both in\u00a0vivo and in\u00a0vitro. In addition, Spearman's test showed that FOXM1 significantly correlated with glycolysis\u2010related genes, especially centromere protein A (CENPA) in datasets (GSE76250, GSE76124, GSE206912, and GSE103091). The effect of silencing\n                    <jats:italic>FOXM1<\/jats:italic>\n                    on the inhibition of CENPA expression, TNBC proliferation, migration, and glycolysis could be recovered by overexpression of CENPA. According to MeRIP, the level of m6A modification on FOMX1 decreased in cells treated with cycloleucine (a m6A inhibitor) compared with that in the control group. The increase in FOXM1 expression caused by YTHDC1 overexpression could be reversed by the m6A inhibitor, which indicated that YTHDC1 enhanced FOXM1 expression depending on m6A modification. Therefore, we concluded that the YTHDC1\u2010m6A modification\/FOXM1\/CENPA axis plays an important role in TNBC progression and glycolysis.\n                  <\/jats:p>","DOI":"10.1111\/cas.16137","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T03:10:20Z","timestamp":1712113820000},"page":"1881-1895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["YTHDC1\u2010dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple\u2010negative breast cancer"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-9154","authenticated-orcid":false,"given":"Xi","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Oncology, The Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-6222","authenticated-orcid":false,"given":"Jianxin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Health Management The Second Hospital Affiliated to Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4314-1649","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9818-9103","authenticated-orcid":false,"given":"Haoran","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Shenzhen Hospital University of Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0825-3048","authenticated-orcid":false,"given":"Nianyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31891-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1177"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5135"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01341-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.029"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.014"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.10.002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2011.09.004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-3566"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S185438"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504014X14078436004987"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2407"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02398-4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5472"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12546"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23448"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty271"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.08.010"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102489"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0461-z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00595-w"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.013"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202371"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.10.145"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-020-01591-8"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14205025"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2019.09.006"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts286"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.102219"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.038"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0419-y"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12739"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00107"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1053-8"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-008-3_17"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03545-x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.978092"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411316"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02373-7"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56490"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00664-9"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1138524"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13212"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.02.004"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.16137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T05:07:47Z","timestamp":1717391267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.16137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/cas.16137"],"URL":"https:\/\/doi.org\/10.1111\/cas.16137","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}