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The majority of metaplastic breast cancers exhibit the characteristics of triple\u2010negative breast cancer and have unfavorable prognoses with a lower survival rate. This subtype often displays gene alterations in the PI3K\/AKT pathway, Wnt\/\u03b2\u2010catenin pathway, and cell cycle dysregulation and demonstrates epithelial\u2013mesenchymal transition, immune response changes, TP53 mutation, EGFR amplification, and so on. Currently, the optimal treatment of metaplastic breast cancer remains uncertain. 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