{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:14:26Z","timestamp":1788927266624,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is limited understanding of epidemiology and time trends of human papilloma virus (HPV)\u2010driven head and neck cancers (HNC) in Japan, especially outside of the oropharynx. To assess HPV\u2010driven HNC, a non\u2010interventional study (BROADEN) of HNC patients diagnosed in 2008\u20132009 and 2018\u20132019 was conducted in Japan. Adult patients with oropharyngeal, nasopharyngeal, laryngeal, hypopharyngeal or oral cavity cancers were included in this study. HPV was centrally tested using p16INK4a immunohistochemistry, HPV\u2010DNA PCR and HPV E6*I mRNA. HPV attributability required positivity in at least two tests (p16INK4a immunohistochemistry, HPV\u2010DNA PCR, HPV E6*I mRNA) in the oropharynx, and HPV\u2010DNA and HPV E6*I mRNA positivity for non\u2010oropharynx sites. Nineteen hospitals included a total of 1108 patients, of whom 981 had valid samples. Men accounted for 82% of HNC diagnoses. Patients in the earlier cohort were younger and included a higher percentage of smokers. There was an increasing trend of HPV\u2010driven oropharyngeal cancer over the last decade, from 44.2% to 51.7%. HPV attribution in nasopharyngeal cancers was 3.2% in 2008\u20132009 and 7.5% in 2018\u20132019; and 4.4% and 0% for larynx respectively. In total, 95.2% of HPV\u2010driven HNC were attributed to HPV genotypes included in the 9\u2010valent HPV vaccine being HPV16 the most prominent genotype. These results suggest that an epidemiologic shift is happening in Japan, with a decrease in smoking and alcohol use and an increase in HPV\u2010driven HNC. The increasing trend of HPV\u2010driven HNC in Japan highlights the need for preventive strategies to mitigate the rise of HPV\u2010driven HNC.<\/jats:p>","DOI":"10.1111\/cas.16230","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T11:27:38Z","timestamp":1717759658000},"page":"2808-2818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Human papillomavirus\u2010driven head and neck cancers in Japan during 2008\u20132009 and 2018\u20132019: The BROADEN study"],"prefix":"10.1111","volume":"115","author":[{"given":"Ken\u2010ichi","family":"Nibu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kobe University, Graduate School of Medicine  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Oridate","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, School of Medicine Yokohama City University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Roset","sequence":"additional","affiliation":[{"name":"IQVIA  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"For\u00e9s\u00a0Maresma","sequence":"additional","affiliation":[{"name":"IQVIA  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cuadras","sequence":"additional","affiliation":[{"name":"IQVIA  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Morais","sequence":"additional","affiliation":[{"name":"MSD France  Puteaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Roberts","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  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