{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:15:45Z","timestamp":1791386145168,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022274","name":"Daiichi Sankyo Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The global phase 3 DESTINY\u2010Breast03 study (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    ; NCT03529110) showed statistically significant and clinically meaningful improvements in progression\u2010free survival (PFS) and overall survival (OS) with trastuzumab deruxtecan (T\u2010DXd) over trastuzumab emtansine (T\u2010DM1) in patients with human epidermal growth factor receptor 2 (HER2)\u2010positive metastatic breast cancer (mBC) previously treated with trastuzumab and a taxane. Here, we report a subgroup analysis of Asian patients enrolled in DESTINY\u2010Breast03. In total, 309 patients (149 in the T\u2010DXd arm and 160 in the T\u2010DM1 arm) from Asian countries and regions were randomized. At data cutoff (July 25, 2022), the median duration of follow\u2010up in the Asian subpopulation was 29.0\u2009months with T\u2010DXd and 26.0\u2009months with T\u2010DM1. The PFS (determined by blinded independent central review) hazard ratio was 0.30 (95% confidence interval 0.22\u20130.41) favoring T\u2010DXd over T\u2010DM1 (median PFS 25.1 vs. 5.4\u2009months). Median OS was not reached in the T\u2010DXd arm and was 37.7\u2009months in the T\u2010DM1 arm. The median treatment duration was 15.4\u2009months with T\u2010DXd and 5.5\u2009months with T\u2010DM1. The incidence of grade\u2009\u22653 drug\u2010related treatment\u2010emergent adverse events was similar between both treatment arms (49.0% vs. 46.5%) and was consistent with the overall DESTINY\u2010Breast03 population. Adjudicated drug\u2010related interstitial lung disease or pneumonitis occurred in 12.9% of patients treated with T\u2010DXd and 2.5% treated with T\u2010DM1, with a higher incidence in Japanese patients; none of these were grade\u2009\u22654 events. These efficacy and safety data reinforce the favorable benefit\u2013risk profile of T\u2010DXd in HER2\u2010positive mBC, including in the Asian subgroup.\n                  <\/jats:p>","DOI":"10.1111\/cas.16234","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T07:54:55Z","timestamp":1720511695000},"page":"3079-3088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Trastuzumab deruxtecan versus trastuzumab emtansine in Asian patients with HER2\u2010positive metastatic breast cancer"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-4718","authenticated-orcid":false,"given":"Hiroji","family":"Iwata","sequence":"first","affiliation":[{"name":"Department of Breast Oncology Aichi Cancer Center Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghe","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Pang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Oncology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Samsung Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Ming","family":"Tseng","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Feng","family":"Chung","sequence":"additional","affiliation":[{"name":"Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiun\u2010Sheng","family":"Huang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne Wing Yan","family":"Chiu","sequence":"additional","affiliation":[{"name":"Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinari","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Egorov","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo Inc.  Basking Ridge New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo, Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo, Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo, Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo, Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"International Breast Cancer Center, Quironsalud Group  Barcelona Spain"},{"name":"Medical Scientia Innovation Research  Barcelona Spain"},{"name":"Faculty of Biomedical and Health Sciences, Department of Medicine Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seock\u2010Ah","family":"Im","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010"},{"key":"e_1_2_12_4_1","unstructured":"National Cancer Institute Surveillance EaERP.Cancer stat facts: female breast cancer subtypes.2023NIH Seer.https:\/\/seer.cancer.gov\/statfacts\/html\/breast\u2010subtypes.html. Accessed 14 November 2023"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-8049(97)10157-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113216"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413513"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.09.019"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.101541"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-023-01505-x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-14-0012"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209124"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0997-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30702-6"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-15-2822"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914510"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)00725-0"},{"key":"e_1_2_12_18_1","unstructured":"US Food and Drug Administration.Enhertu\u00ae (Fam\u2010Trastuzumab Deruxtecan\u2010Nxki) for Injection for Intravenous Use: US Prescribing Information.2019https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/761139s011lbl.pdf. Accessed May 10 2023"},{"key":"e_1_2_12_19_1","unstructured":"Pharmaceuticals and Medical Devices Agency.New Drugs Approved in FY 2019.2020https:\/\/www.pmda.go.jp\/files\/000267880.pdf. Accessed June 25 2024"},{"key":"e_1_2_12_20_1","unstructured":"Korea Ministry of Food and Drug Safety.New Drugs Approved in FY 2019.2020https:\/\/www.mfds.go.kr\/eng\/brd\/m_19\/view.do?seq=70438. Accessed August 9 2023"},{"key":"e_1_2_12_21_1","unstructured":"European Medicines Agency.Enhertu (trastuzumab deruxtecan): summary of product charactristics.2021https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/enhertu\u2010epar\u2010product\u2010information_en.pdf. Accessed May 10 2023"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115022"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)02420-5"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-021-01239-8"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0620"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100554"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2013.09.001"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100356"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.16234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:23:11Z","timestamp":1728472991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.16234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/cas.16234"],"URL":"https:\/\/doi.org\/10.1111\/cas.16234","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"2024-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}