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However, understanding the molecular basis of such heterogeneity has remained elusive. This study aimed to elucidate the molecular landscape of neuroendocrine\u2010like bladder tumors, focusing on the involvement of \u03b2\u2010catenin localization. Analyzing the transcriptome data and benefiting from the molecular classification tool, we undertook an in\u2010depth analysis of muscle\u2010invasive bladder cancers to uncover the molecular characteristics of the neuroendocrine\u2010like differentiation. The study explored the contribution of transcription factors and chromatin remodeling complexes to neuroendocrine differentiation in bladder cancer. The study revealed a significant correlation between \u03b2\u2010catenin localization and neuroendocrine differentiation in muscle\u2010invasive bladder tumors, highlighting the molecular complexity of neuroendocrine\u2010like tumors. Enrichment of YY1 transcription factor, E2F family members, and Polycomb repressive complex components in \u03b2\u2010catenin\u2010positive tumors suggest their potential contribution to neuroendocrine phenotypes. Our findings contribute valuable insights into the molecular complexity of neuroendocrine\u2010like bladder tumors. By identifying potential therapeutic targets and refining diagnostic strategies, this study advances our understanding of endocrinology in the context of bladder cancer. Further investigations into the functional implications of these molecular relationships are warranted to enhance our knowledge and guide future therapeutic interventions.<\/jats:p>","DOI":"10.1111\/cas.16275","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T05:56:16Z","timestamp":1721022976000},"page":"2985-2997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nucleocytoplasmic \u03b2\u2010catenin expression contributes to neuroendocrine differentiation in muscle invasive bladder cancer"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-5836","authenticated-orcid":false,"given":"Burcu","family":"Akman","sequence":"first","affiliation":[{"name":"Basic and Translational Research Program \u0130zmir Biomedicine and Genome Center  \u0130zmir 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