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Their composition typically changes in response to the metaplastic sequence triggered by\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection. This alteration in gastric mucins is also observed in cases of gastric cancer, although the precise connection between mucin expressions and gastric carcinogenesis remains uncertain. This review first introduces the relationship between mucin expressions and gastric metaplasia or cancer observed in humans and mice. Additionally, we discuss potential pathogenic mechanisms of how aberrant mucins and their glycans affect gastric carcinogenesis. Finally, we summarize challenges to target tumor\u2010specific glycans by utilizing lectin\u2010drug conjugates that can bind to specific glycans. Understanding the correlation and mechanism between these mucin expressions and gastric carcinogenesis could pave the way for new strategies in gastric cancer treatment.\n                  <\/jats:p>","DOI":"10.1111\/cas.16282","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T01:39:37Z","timestamp":1721439577000},"page":"2853-2861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The role of gastric mucins and mucin\u2010related glycans in gastric cancers"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-7046","authenticated-orcid":false,"given":"Junya","family":"Arai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, The Institute for Medical Science Asahi Life Foundation  Chuo\u2010ku, Tokyo Japan"},{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-2499","authenticated-orcid":false,"given":"Yoku","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tateno","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biotechnology Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, The Institute for Medical Science Asahi Life Foundation  Chuo\u2010ku, Tokyo 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