{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:20:07Z","timestamp":1768468807993,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is recognized that lncRNA BBOX1\u2010AS1 exerts a crucial oncogenic property in several cancer types. However, the functions and underlying mechanisms of BBOX1\u2010AS1 in the epithelial\u2013mesenchymal transition (EMT) process of gastric cardia adenocarcinoma (GCA) have remained unclarified. The findings of this study demonstrated that GCA tissues had elevated BBOX1\u2010AS1 expression levels, which was associated with a worse prognosis in GCA patients. BBOX1\u2010AS1 dramatically enhanced cell proliferation, invasion, and TGF\u2010\u03b21\u2010induced the EMT process in\u00a0vitro. Further mechanism analysis revealed that BBOX1\u2010AS1 could combine with CtBP2 and strengthen the interaction of CtBP2 and ZEB1. BBOX1\u2010AS1 might regulate the E\u2010cadherin expression through CtBP2\/ZEB1 transcriptional complex\u2010mediated transcriptional repression, further affecting the activation of the Wnt\/\u03b2\u2010catenin pathway and the EMT process. Overall, our findings demonstrate that BBOX1\u2010AS1 might act as an lncRNA associated with EMT for facilitating GCA advancement via interaction with CtBP2 to facilitate the activation of Wnt\/\u03b2\u2010catenin pathway and the EMT process, which indicated that it might function as an exploitable treatment target for GCA patients.<\/jats:p>","DOI":"10.1111\/cas.16350","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T05:34:51Z","timestamp":1727242491000},"page":"3875-3889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>BBOX1<\/scp>\u2010<scp>AS1<\/scp> promotes gastric cardia adenocarcinoma progression via interaction with <scp>CtBP2<\/scp> to facilitate the epithelial\u2013mesenchymal transition process"],"prefix":"10.1111","volume":"115","author":[{"given":"Wenxu","family":"Zou","sequence":"first","affiliation":[{"name":"Hebei Cancer Institute The Fourth Hospital of 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