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We focused on the prevalence, clinicopathological features, and survival impact of homologous recombination repair (HRR) PVs in patients with epithelial ovarian cancer (EOC). This was a multicenter retrospective cohort study, and 1248 patients with EOC were registered. Eligible patients (<jats:italic>n<\/jats:italic>\u2009=\u20091112) underwent germline DNA analysis for 26 cancer predisposition genes, including nine HRR\u2010related genes, such as <jats:italic>BRCA1\/2<\/jats:italic>, <jats:italic>BRIP1<\/jats:italic>, <jats:italic>PALB2<\/jats:italic>, <jats:italic>RAD51C\/D<\/jats:italic>, and <jats:italic>ATM<\/jats:italic>. The associations between clinicopathological factors and HRR\u2010related PVs were examined. Kaplan\u2013Meier and Cox regression analyses were conducted. Among 1091 analyzed patients, 153 (14.0%) carried PVs and 140 (12.8%) were HRR\u2010related. HRR\u2010PV\u2010positive status significantly correlated with serous carcinoma (22.9% vs. 4.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and advanced disease (18.5% vs. 5.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The HRR\u2010PV\u2010positive group exhibited higher prevalence of personal breast (12.9%) and familial breast\/ovarian (29.2%) cancer history. HRR status independently improved overall survival in stage III\/IV disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) but not progression\u2010free survival. HRR\u2010related germline PVs exhibit distinct clinicopathological features with survival implications. Variants were significantly associated with serous carcinoma and advanced disease, underscoring the importance of genetic testing to develop individualized EOC treatment strategies. Considering the study period (2000\u20132019), the limited use of bevacizumab and poly (ADP\u2010ribose) polymerase inhibitors as maintenance therapy should be recognized.<\/jats:p>","DOI":"10.1111\/cas.16367","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T14:44:10Z","timestamp":1728571450000},"page":"3952-3962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and outcomes of germline pathogenic variants of homologous recombination repair genes in ovarian cancer"],"prefix":"10.1111","volume":"115","author":[{"given":"Maiko","family":"Miwa","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Saitama Medical University International Medical Center  Hidaka Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology 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