{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:00:47Z","timestamp":1787065247159,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H03111"],"award-info":[{"award-number":["21H03111"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19626"],"award-info":[{"award-number":["22K19626"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H05104"],"award-info":[{"award-number":["JP17H05104"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K22719"],"award-info":[{"award-number":["JP19K22719"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K08455"],"award-info":[{"award-number":["JP22K08455"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H03101"],"award-info":[{"award-number":["JP23H03101"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017682","name":"Japanese Society of Hematology","doi-asserted-by":"publisher","award":["23195"],"award-info":[{"award-number":["23195"]}],"id":[{"id":"10.13039\/100017682","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple myeloma (MM) cells and osteoclasts (OCs) activate with each other to cause drug resistance. Human Th1\u2010like V\u03b39V\u03b42 (\u03b3\u03b4) T cells, important effectors against tumors, can be expanded and activated ex\u00a0vivo by the aminobisphosphonate zoledronic acid in combination with IL\u20102. We previously reported that the expanded \u03b3\u03b4 T cells effectively targeted and killed OCs as well as MM cells. Because the expanded \u03b3\u03b4 T cells expressed CD16 on their surface, we investigated the utilization of the expanded \u03b3\u03b4 T cells for antibody\u2010dependent cellular cytotoxicity (ADCC). Although the expanded \u03b3\u03b4 T cells alone induced cell death in MM cell lines, the addition of the anti\u2010SLAMF7 monoclonal antibody elotuzumab (ELO) further enhanced their cytotoxic activity only against SLAMF7\u2010expressing MM cell lines and primary MM cells. Intriguingly, ELO was also able to enhance \u03b3\u03b4 T cell\u2010induced cell death against OCs cultured alone, and against both MM cells and OCs in their coculture settings. SLAMF7 was found to be highly expressed in OCs differentiated in\u00a0vitro from monocytes by receptor activator of nuclear factor\u2010\u03ba B ligand and M\u2010CSF, although monocytes only marginally expressed SLAMF7. These results demonstrate that SLAMF7 is highly expressed in both MM cells and OCs, and that the ex\u00a0vivo\u2010expanded \u03b3\u03b4 T cells can exert ELO\u2010mediated ADCC against SLAMF7\u2010expressing MM cells and OCs besides their direct cytotoxic activity. Further study is warranted for the innovative utilization of \u03b3\u03b4 T cells.<\/jats:p>","DOI":"10.1111\/cas.16401","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T21:39:29Z","timestamp":1731965969000},"page":"559-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Elotuzumab\u2010mediated\n                    <scp>ADCC<\/scp>\n                    with Th1\u2010like\n                    <scp>V\u03b39V\u03b42<\/scp>\n                    T cells to disrupt myeloma\u2013osteoclast interaction"],"prefix":"10.1111","volume":"116","author":[{"given":"Yusuke","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Medical Technology Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tenshin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Teramachi","sequence":"additional","affiliation":[{"name":"Department of Oral Function and Anatomy, Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Sumitani","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Oura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Sogabe","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Maruhashi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingen","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Miki","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine and Cell Therapy Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Bioregulatory Sciences Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hiasa","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-7471","authenticated-orcid":false,"given":"Takeshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Hematology Kawashima Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006540"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-023-01403-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0885-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00722-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1167443"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.273"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01492"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-107292"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017008813"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17896"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.16401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T08:44:42Z","timestamp":1738399482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.16401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/cas.16401"],"URL":"https:\/\/doi.org\/10.1111\/cas.16401","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}