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LHPP, known for its tumor\u2010suppressive effects, has an undefined role in BRCA. We found reduced LHPP protein in BRCA tissues, with lower levels correlating with poor patient outcomes. In\u00a0vitro studies show LHPP inhibits BRCA cell proliferation, migration, invasion, and stemness. In\u00a0vivo xenograft models support LHPP's role in curbing tumorigenesis and lung metastasis. Mechanistically, LHPP interacts with ERK and P38 MAPK, leading to their dephosphorylation and suppression of the MAPK pathway. 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