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Tinengotinib (TT\u201000420) is a novel, multi\u2010targeted, and spectrally selective small\u2010molecule kinase inhibitor that has shown significant inhibitory effects on certain solid tumors in preclinical studies. However, its role and mechanism of action in SCLC remain unclear. In this study, we demonstrated that tinengotinib effectively inhibited SCLC cell proliferation, especially highly expressing NeuroD1 (SCLC\u2010N), in the SCLC cell line\u2010derived xenograft (CDX) model and the malignant pleural effusion cell model of patients with SCLC. When combined with etoposide\/cisplatin, it synergistically inhibited SCLC growth. Tinengotinib regulates proliferation, apoptosis, migration, cell cycle and angiogenesis in SCLC cells. Mechanistic studies revealed that c\u2010Myc expression may be a key factor influencing the effect of tinengotinib in SCLC\u2010N. 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