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Defects in the APM generally result in the downregulation of surface MHC class I (MHC\u2010I) levels. Here, we show that the downregulation of a component of the peptide loading complex (PLC), tapasin, in tumors conversely induces CD8<jats:sup>+<\/jats:sup> T\u2010cell responses and inhibits tumor growth in\u00a0vivo. Loss of tapasin enhanced the anti\u2010tumor effects of immune checkpoint blockade (ICB) in mouse non\u2010small cell lung and colon cancer models. In contrast to \u03b22m\u2010deficient tumors, the reduced levels of MHC\u2010I in tapasin\u2010deficient tumors were restored by IFN\u2010\u03b3 treatment, allowing them to be recognized by CD8<jats:sup>+<\/jats:sup> T cells. These results suggest the presence of a reactive CD8<jats:sup>+<\/jats:sup> T\u2010cell fraction and the ability of immune surveillance to eliminate tumor variants with impaired tapasin expression.<\/jats:p>","DOI":"10.1111\/cas.70027","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:03:08Z","timestamp":1740546188000},"page":"1203-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Loss of Tapasin in Tumors Potentiates T\u2010Cell Recognition and Anti\u2010Tumor Effects of Immune Checkpoint Blockade"],"prefix":"10.1111","volume":"116","author":[{"given":"Keigo","family":"Moniwa","sequence":"first","affiliation":[{"name":"Department of Pathology Sapporo Medical University  Sapporo Japan"},{"name":"Department of Respiratory Medicine and Allergology Sapporo Medical University  Sapporo 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