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We report a case of GSRCC in a 10\u2010year\u2010old Chinese boy with no family history of cancer. The diagnosis was established via gastroscopy, endoscopic ultrasound, and imaging examinations. Early detection allowed a successful distal gastrectomy with D2 lymph node dissection. Postoperative whole\u2010exome sequencing (WES) revealed no clinically significant mutations but identified some somatic alterations. Notably, gastric biopsy pathology demonstrated strong positivity for <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>) infection. Additionally, we comprehensively reviewed the existing pediatric GSRCC cases, suggesting the potential role of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection in the pathogenesis of pediatric gastric cancer.<\/jats:p>","DOI":"10.1111\/cas.70112","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:05:19Z","timestamp":1749614719000},"page":"2064-2074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastric Signet Ring Cell Carcinoma in a <i>Helicobacter pylori<\/i>\u2010Positive 10\u2010Year\u2010Old Boy: A Case Report and Literature Review"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7419-433X","authenticated-orcid":false,"given":"Xiaoxuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology The Affiliated Hospital of Qingdao University  Qingdao 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