{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:29:11Z","timestamp":1792114151123,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peritoneal metastasis is a lethal manifestation of gastric cancer, with poor prognosis and limited treatment options. A targeted drug delivery system minimizing systemic toxicity is urgently needed. Given that platelets form stable aggregates with gastric cancer cells, we explored their feasibility as a drug carrier. We engineered paclitaxel\u2010loaded platelets and assessed their antitumor efficacy using human gastric cancer cell lines. To evaluate therapeutic performance in\u00a0vivo, a murine model of peritoneal metastasis was established with BALB\/c\u2010Slc\u2010nu\/nu mice. Paclitaxel was administered intraperitoneally at 25\u2009mg\/kg per week in both the free paclitaxel and paclitaxel\u2010loaded platelets groups, via injection every 7\u2009days for a total of 8 times. Paclitaxel\u2010loaded platelets exhibited strong adhesion to gastric cancer cells, efficiently delivering paclitaxel intracellularly. Functional assays confirmed platelet activation capacity was preserved post drug loading. In\u00a0vitro, paclitaxel\u2010loaded platelets significantly inhibited tumor cell viability (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In\u00a0vivo, they markedly reduced systemic drug exposure (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.047) and significantly improved antitumor efficacy and survival versus free paclitaxel (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Our findings highlight platelets as a novel drug delivery system for peritoneal metastasis in gastric cancer. Leveraging their tumor\u2010homing properties and biocompatibility, this approach enables targeted intraperitoneal chemotherapy, representing a promising strategy for this treatment\u2010refractory disease.\n                  <\/jats:p>","DOI":"10.1111\/cas.70167","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T02:39:57Z","timestamp":1754447997000},"page":"2858-2867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential of Platelet\u2010Based Drug Delivery System for Treating Peritoneal Metastasis of Gastric Cancer"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-4414","authenticated-orcid":false,"given":"Takashi","family":"Nakayama","sequence":"first","affiliation":[{"name":"First Department of Surgery, Faculty of Medicine University of Yamanashi  Yamanashi 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