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Despite its clinical significance, the molecular drivers of LM in PC remain poorly characterized, and few validated biomarkers or therapeutic targets are currently available. Our study identifies 7\u2010dehydrocholesterol reductase (DHCR7), a terminal enzyme in cholesterol biosynthesis, as significantly upregulated in PC tissues and closely correlated with LM progression. In\u00a0vitro experiments demonstrated that DHCR7 enhances the proliferation, invasion, and migration ability in PC cells, and in\u00a0vivo experiments demonstrated that DHCR7 promotes LM of PC. The mechanism of DHCR7 promoting LM may be mediated by elevating cholesterol synthesis of PC cells and then activating the PI3K\u2010Akt signaling pathway. Taken together, our findings uncover a novel molecular mechanism underlying LM in PC and highlight DHCR7 as a possible predictive biomarker or interventional target.<\/jats:p>","DOI":"10.1111\/cas.70185","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T03:00:30Z","timestamp":1756868430000},"page":"3196-3208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>DHCR7<\/scp>\n                    Promotes Liver Metastasis of Pancreatic Cancer Through\n                    <scp>PI3K<\/scp>\n                    \u2010Akt Signaling Pathway"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8837-1465","authenticated-orcid":false,"given":"Yu","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pancreatic and Metabolic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing 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