{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:17:27Z","timestamp":1792700247967,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastric cancer is a prevalent and clinically significant gastrointestinal malignancy worldwide. Gastric cancer is characterized by limited treatment efficacy and a high recurrence rate. In this study, we found that LGALS9 was highly expressed in gastric cancer and may contribute to disease progression by modulating the infiltration of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Genetic knockout of LGALS9 reversed T cell function, attenuated immunosuppression, and enhanced the cytotoxic activity of T cells to kill gastric cancer cells. Furthermore, miR\u2010491\u20105p was identified as a potential suppressor in gastric cancer. The microRNA miR\u2010491\u20105p regulated T cell\u2010mediated immunity by targeting and inhibiting LGALS9, which was similar to the effect of LGALS9 knockout. Overall, the key target LGALS9 and its inhibitor miR\u2010491\u20105p represent promising potential for treating gastric cancer.\n                  <\/jats:p>","DOI":"10.1111\/cas.70232","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:41:28Z","timestamp":1761928888000},"page":"50-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The\n                    <scp>LGALS9<\/scp>\n                    \/\n                    <scp>miR<\/scp>\n                    \u2010491\u20105p Axis Regulates\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T Cell Function and Inhibits the Progression of Gastric Cancer"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-8523","authenticated-orcid":false,"given":"Wanzhong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology 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