{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T07:48:56Z","timestamp":1775720936524,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is a known risk factor for breast cancer, particularly in postmenopausal women. Genome\u2010wide association studies have identified single nucleotide polymorphisms (SNPs) associated with body mass index (BMI). We conducted a case\u2013control study with 1273 breast cancer cases and 4816 controls to examine whether five BMI\u2010associated SNPs (rs939584 [\n                    <jats:italic>TMEM18<\/jats:italic>\n                    ], rs4409766 [\n                    <jats:italic>BORCS7\u2010ASMT<\/jats:italic>\n                    ], rs6265 [\n                    <jats:italic>BDNF<\/jats:italic>\n                    ], rs1927790 [\n                    <jats:italic>HS6ST3<\/jats:italic>\n                    ], rs1421085 [\n                    <jats:italic>FTO<\/jats:italic>\n                    ]) influence breast cancer risk through BMI\u2010dependent or \u2010independent pathways using mediation analysis. For postmenopausal breast cancer, rs6265 (C\u2009&gt;\u2009T) exhibited a carcinogenic direct effect (odds ratio [OR]\u2009=\u20091.18, 95% confidence interval [CI]: 1.04\u20131.34) along with a protective indirect effect through changes in BMI (OR\u2009=\u20090.98, 95% CI 0.96\u20130.99), while rs1421085 (T\u2009&gt;\u2009C) showed a carcinogenic indirect effect (OR\u2009=\u20091.03, 95% CI 1.00\u20131.05). No significant associations were observed for any SNPs in premenopausal breast cancer. These findings suggest that two BMI\u2010associated genetic variants, rs6265 and rs1421085, influence postmenopausal breast cancer risk through changes in BMI, and that rs6265 also exerts a direct effect through pathways independent of BMI, providing insight into a previously uncharacterized association between obesity\u2010related genetic factors and breast cancer and highlighting the potential utility of genetic profiling in personalized risk assessment.\n                  <\/jats:p>","DOI":"10.1111\/cas.70239","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:39:46Z","timestamp":1761795586000},"page":"226-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Impact of\n                    <scp>BMI<\/scp>\n                    \u2010Associated Genetic Variants on Breast Cancer Risk: Insights From Mediation Analysis"],"prefix":"10.1111","volume":"117","author":[{"given":"Yuri","family":"Ando","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-3429","authenticated-orcid":false,"given":"Yuriko N.","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Iwashita","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Japan"},{"name":"Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Kasugai","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-1147","authenticated-orcid":false,"given":"Isao","family":"Oze","sequence":"additional","affiliation":[{"name":"Division of Cancer Information and Control Aichi Cancer Center Research Institute  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-4837","authenticated-orcid":false,"given":"Masahiro","family":"Nakatochi","sequence":"additional","affiliation":[{"name":"Public Health Informatics Unit, Department 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