{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:04:06Z","timestamp":1788951846078,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    First\u2010line atezolizumab combination therapies were approved for the treatment of metastatic non\u2010small cell lung cancer (NSCLC) based on results from the global phase 3 trials IMpower130, IMpower132, and IMpower150. These trials reported 12\u2010month overall survival (OS) rates of 60%\u201367% with atezolizumab combination therapy. J\u2010TAIL\u20102 (NCT04501497), a prospective, multicenter, observational study, evaluated atezolizumab combination therapy in routine clinical practice in Japan. Patients \u2265\u200920\u2009years old with NSCLC received atezolizumab plus carboplatin and nab\u2010paclitaxel (atezo + CnP), atezolizumab plus carboplatin or cisplatin plus pemetrexed (atezo + PP), or atezolizumab plus bevacizumab plus carboplatin and paclitaxel (atezo + bev\u2009+\u2009CP) in clinical practice. The primary endpoint was the 12\u2010month OS rate. Secondary endpoints included OS, progression\u2010free survival, and subgroup analyses, including IMpower\u2010unlike (did not meet the main eligibility criteria of each IMpower trial) and IMpower\u2010like patients. In total, 814 patients were enrolled (atezo + CnP,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009217; atezo + PP,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009211; atezo + bev\u2009+\u2009CP,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009386). The IMpower\u2010unlike group included patients with Eastern Cooperative Oncology Group performance status \u2265\u20092, autoimmune disease, or interstitial lung disease. Twelve\u2010month OS rates (95% confidence interval [CI]) were 62.9% (55.8\u201369.2), 72.1% (65.2\u201377.9), and 68.3% (63.2\u201372.9) with atezo + CnP, atezo + PP, and atezo + bev\u2009+\u2009CP, respectively. OS hazard ratios (95% CI) in the IMpower\u2010unlike vs. \u2010like subgroups were 1.36 (0.91\u20132.05), 1.08 (0.70\u20131.68), and 1.49 (1.09\u20132.06), respectively. No new safety signals were observed. Real\u2010world efficacy and safety for each atezolizumab combination were comparable to those in the relevant IMpower trials.\n                  <\/jats:p>","DOI":"10.1111\/cas.70242","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:40:27Z","timestamp":1765453227000},"page":"727-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atezolizumab + Chemotherapy for Advanced Non\u2010Small Cell Lung Cancer in Japanese Clinical Practice (J\u2010TAIL\u20102)"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-0481","authenticated-orcid":false,"given":"Hiroshige","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology Kansai Medical University  Hirakata Japan"},{"name":"Department of Respiratory Medicine and Clinical Immunology Dokkyo Medical University Saitama Medical Center  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-4165","authenticated-orcid":false,"given":"Makoto","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5180-3933","authenticated-orcid":false,"given":"Kadoaki","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Osoegawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-6321","authenticated-orcid":false,"given":"Eiki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanazawa University Hospital  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6837-6392","authenticated-orcid":false,"given":"Eisaku","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare, Narita Hospital  Narita Japan"},{"name":"Department of General Thoracic Surgery Chiba University Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Misumi","sequence":"additional","affiliation":[{"name":"Department of Data Science National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Saitama Cancer Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Thoracic Oncology Kobe Minimally Invasive Cancer Center  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kisohara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kasukabe Medical Center  Kasukabe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Kuyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology NHO Kyushu Cancer Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Miwa","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd.  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