{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:07:47Z","timestamp":1784675267990,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272669"],"award-info":[{"award-number":["82272669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473171"],"award-info":[{"award-number":["82473171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX24_0776"],"award-info":[{"award-number":["SJCX24_0776"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019870","name":"Cancer Foundation of China","doi-asserted-by":"publisher","award":["CFCSSSQ017"],"award-info":[{"award-number":["CFCSSSQ017"]}],"id":[{"id":"10.13039\/501100019870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    FLAURA2 has demonstrated that third\u2010generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR\u2010TKIs) plus chemotherapy brought a significant survival benefit over EGFR\u2010TKI monotherapy. This suggests that EGFR\u2010TKIs combined with chemotherapy may be a viable therapeutic strategy. Our study aimed to evaluate the efficacy, safety, and progression pattern of third\u2010generation EGFR\u2010TKIs combined with chemotherapy in advanced\n                    <jats:italic>EGFR<\/jats:italic>\n                    \u2010mutant (\n                    <jats:italic>EGFR<\/jats:italic>\n                    m) non\u2010small cell lung cancer (NSCLC) in the real world. This study designed as an observational, retrospective, single\u2010center, real\u2010world project enrolled 382 NSCLC individuals receiving third\u2010generation EGFR\u2010TKIs combined with platinum\u2010based chemotherapy as first\u2010line therapy. The primary end point was progression\u2010free survival (PFS), and secondary end points included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). From July 2016 to May 2024, 382 patients were retrospectively included for the analysis. Of these patients, 120, 165, and 97 patients received osimertinib, aumolertinib, and furmonertinib plus chemotherapy as first\u2010line therapy, respectively. Overall, the median follow\u2010up duration was 34.6\u2009months (95% CI: 32.2\u201335.6), the median PFS was 30.9\u2009months (95% CI: 27.5\u201339.3), and the median OS was 53.9\u2009months (95% CI: 46.2\u2013NR). Overall, the ORR was 76.4% and the DCR was 98.2%. One hundred thirty\u2010seven (35.9%) individuals experienced Grade 3 or higher AEs. Different third\u2010generation EGFR\u2010TKI groups show no statistically significant difference in PFS (HR\u2009=\u20090.75; 95% CI: 0.51\u20131.10;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.25) after inverse probability of treatment weighting (IPTW), nor in AEs or severe AEs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.852;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.502). First\u2010line third\u2010generation EGFR\u2010TKI combined with pemetrexed\u2010based chemotherapy demonstrated a favorable ORR and PFS benefit in advanced\n                    <jats:italic>EGFR<\/jats:italic>\n                    m NSCLC.\n                  <\/jats:p>","DOI":"10.1111\/cas.70269","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:34:22Z","timestamp":1764401662000},"page":"476-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Third\u2010Generation\n                    <scp>EGFR<\/scp>\n                    \u2010\n                    <scp>TKIs<\/scp>\n                    Combined With Chemotherapy in Advanced Non\u2010Small Cell Lung Cancer: A Real\u2010World Study"],"prefix":"10.1111","volume":"117","author":[{"given":"YuQin","family":"Jiang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-6956","authenticated-orcid":false,"given":"Qi","family":"Liang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangyin Clinical College of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohan","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-8617","authenticated-orcid":false,"given":"Renhua","family":"Guo","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60735-0"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0579-CP"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae336"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904554"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01391-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713137"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00168-0"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02641"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.7576"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01695-2"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.07.1143"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.02.023"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306434"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.12.018"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2024.101260"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35778"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.11.022"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-021-00794-6"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO-24-00818"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.04.003"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.09.1453"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.70269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T13:27:16Z","timestamp":1769952436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.70269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/cas.70269"],"URL":"https:\/\/doi.org\/10.1111\/cas.70269","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2025-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}