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Its role in glioblastoma (GBM), the most aggressive brain cancer, remains incompletely understood. Single\u2010cell RNA sequencing data from a published GBM dataset were reanalyzed to assess YAP expression across cell populations. YAP was silenced via shRNA in GBM cell lines (U\u2010251 MG, U\u201087 MG) and patient\u2010derived GBM cells. Resveratrol (RV), a natural blood\u2013brain barrier\u2013permeable compound, was evaluated for growth inhibition and YAP\u2010targeted effects. Functional assays measured proliferation, spheroid formation, migration, invasion, and drug sensitivity. YAP and its cofactor TEAD were highly upregulated in GBM cells compared with normal brain and stromal cells. YAP depletion by shRNA suppressed proliferation, spheroid formation, migration, and invasion. RV treatment similarly inhibited YAP expression, reducing proliferation and viability in monolayer and 3D spheroid cultures, and impairing migration and invasion via epithelial\u2013mesenchymal transition (EMT) inhibition. RV\u2010mediated YAP suppression also enhanced sensitivity to temozolomide (TMZ) and carmustine (BCNU), increasing their cytotoxicity in GBM cells. RV acts as a novel YAP inhibitor in GBM, impairing malignant phenotypes and potentiating the effects of standard chemotherapy. These findings support RV as a potential adjunct in YAP\u2010targeted GBM therapy, warranting further in\u00a0vivo validation for clinical translation.<\/jats:p>","DOI":"10.1111\/cas.70317","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:47:48Z","timestamp":1768038468000},"page":"695-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resveratrol as a Novel\n                    <scp>YAP<\/scp>\n                    Inhibitor Targeting Glioblastoma Progression and Sensitizing to Chemotherapy"],"prefix":"10.1111","volume":"117","author":[{"given":"Wannawat","family":"Khotchawan","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"Siriraj Center of Excellence for Stem Cell Research (SiSCR), faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 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