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Recent investigations suggest that mitophagy may constitute a potential therapeutic target for PC. This study aims to elucidate the molecular mechanisms underlying circ\u20100030167's regulation of PC, extending our prior investigations. mRNA sequencing analysis demonstrated significant enrichment of mitophagy\u2010related signaling pathways in PC cells overexpressing circ\u20100030167. Integrated analysis utilizing RNA\u2010binding protein (RBP) databases identified IGF2BP1 as a binding partner, a finding corroborated by RNA pull\u2010down assays, RNA immunoprecipitation (RIP) experiments, and fluorescence in\u00a0situ hybridization (FISH) validation. Cell\u2010derived xenograft (CDX) assays confirmed that circ\u20100030167 enhances IGF2BP1 protein stability. Subsequent bioinformatic analysis combined with mRNA\u2010seq data revealed HMOX1 as a downstream target gene within the circ\u20100030167\/IGF2BP1\u2010mediated mitophagy pathway. Functional assays measuring ferroptosis\u2010related parameters\u2014cell viability, reactive oxygen species (ROS) levels, malondialdehyde (MDA) content, and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    concentration\u2014established that the circ\u20100030167\/IGF2BP1 axis modulates mitophagy\u2010mediated ferroptosis through HMOX1. Furthermore, in\u00a0vivo animal studies demonstrated that circ\u20100030167 overexpression markedly suppresses PC tumor growth. In conclusion, our findings identify the circ\u20100030167\/IGF2BP1\/HMOX1 axis as a critical regulatory factor targeting mitochondria\u2010mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies.\n                  <\/jats:p>","DOI":"10.1111\/cas.70356","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:54:52Z","timestamp":1772967292000},"page":"1362-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circ\u20100030167\/\n                    <scp>IGF2BP1<\/scp>\n                    Induces Mitophagy\u2010Mediated Ferroptosis via\n                    <scp>HMOX1 mRNA<\/scp>\n                    Stabilization in Pancreatic Cancer"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8102-6813","authenticated-orcid":false,"given":"Qun","family":"Zhao","sequence":"first","affiliation":[{"name":"Research 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