{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:21:11Z","timestamp":1791260471872,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polymer\u2010based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site\u2010specific delivery of therapeutic agents. Among polysaccharide\u2010derived materials, chitosan stands out for its biodegradability, biocompatibility, and intrinsic mucoadhesive properties that promote efficient drug encapsulation and enhanced cellular internalization. Surface PEGylation the conjugation of polyethylene glycol (PEG) chains further augments the physicochemical and biological performance of chitosan nanoparticles by enhancing colloidal stability, extending systemic circulation, and reducing opsonization by the reticuloendothelial system. In addition, ligand\u2010mediated functionalization facilitates active tumor targeting and selective intracellular delivery, thereby improving therapeutic efficacy while minimizing off\u2010target toxicity. This review critically summarizes recent advances in the design, synthesis, and functional modification of PEGylated chitosan nanoparticles, with emphasis on their pharmacokinetic behavior, drug release mechanisms, and anticancer performance. Comparative insights into other polymeric and lipid\u2010based nanocarrier systems are also provided. Finally, current challenges, safety considerations, and translational perspectives are discussed, underscoring the promise of PEGylated chitosan nanoplatforms as next\u2010generation biomaterials for precision oncology.<\/jats:p>","DOI":"10.1111\/cas.70361","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:31:22Z","timestamp":1775014282000},"page":"1531-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>PEGylated<\/scp>\n                    Chitosan Nanoparticles: Engineering Multifunctional Platforms for Targeted Cervical and Lung Cancer Treatment"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-769X","authenticated-orcid":false,"given":"Prashant","family":"Kesharwani","sequence":"first","affiliation":[{"name":"Next\u2010Generation Translational Nanomedicine Laboratory, Department of Pharmaceutical Sciences Dr. Harisingh Gour Vishwavidyalaya (A Central University)  Sagar Madhya Pradesh India"},{"name":"Department of Research and Development Asia University  Taichung Taiwan"},{"name":"University Institute of Pharma Sciences Chandigarh University  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Applied Medical Sciences Khamis Mushait, King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadma","family":"Wahab","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Gupta","sequence":"additional","affiliation":[{"name":"Graphic Era Hill University  Dehradun India"},{"name":"School of Allied Medical Sciences Lovely Professional University  Phagwara Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khang Wen","family":"Goh","sequence":"additional","affiliation":[{"name":"Faculty of Data Science and Information Technology INTI International University  Nilai Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105661"},{"key":"e_1_2_13_3_1","first-page":"411","article-title":"Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials","volume":"4","author":"Elieh\u2010Ali\u2010Komi D.","year":"2016","journal-title":"International Journal of Advanced Research"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md21040211"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2089296"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.10.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114079"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.09.012"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11080771"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.033"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114724"},{"key":"e_1_2_13_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08674","article-title":"Drug Release Study of the Chitosan\u2010Based Nanoparticles","volume":"8","author":"Herdiana Y.","year":"2021","journal-title":"Heliyon"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev\u20102023\u20100205"},{"key":"e_1_2_13_15_1","volume-title":"StatPearls","author":"Wadhwa R. 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