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In particular, the incidence of several early\u2010onset digestive system cancers, including cancers of the esophagus, stomach, colorectum, liver, extrahepatic bile duct, gallbladder, and pancreas, has been reported to be increasing in multiple regions. To elucidate carcinogenic mechanisms and develop effective prevention, earlier detection, and treatment strategies, further evidence is needed on risk factors and clinical, pathological, and molecular characteristics. In this review, we summarize the current evidence on these characteristics, highlight shared and distinct features across organ sites, and discuss research opportunities to address the rising burden of early\u2010onset digestive system cancers.<\/jats:p>","DOI":"10.1111\/cas.70363","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:19:47Z","timestamp":1773875987000},"page":"1223-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites"],"prefix":"10.1111","volume":"117","author":[{"given":"Nobuhiro","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of General Surgical Science Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Ugai","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Integrative Cancer Research National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Epidemiology Harvard T.H. 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