{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:09:11Z","timestamp":1777910951547,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The clinical significance of comprehensive genomic profiling (CGP) has been established in metastatic castration\u2010resistant prostate cancer (PC). However, the role of genomic profiling in localized PC remains unclear. In this exploratory study, we evaluated somatic genomic alterations in localized PC using an in\u2010house CGP platform to examine their associations with biochemical recurrence (BCR) and recurrence\u2010free survival (RFS) after radical prostatectomy. DNA extracted from surgical specimens of 314 patients with localized PC was analyzed for alterations in 164 cancer\u2010related genes. Six genes (\n                    <jats:italic>PTEN<\/jats:italic>\n                    ,\n                    <jats:italic>BRCA2<\/jats:italic>\n                    ,\n                    <jats:italic>POLD1<\/jats:italic>\n                    ,\n                    <jats:italic>ERBB3<\/jats:italic>\n                    ,\n                    <jats:italic>MYC<\/jats:italic>\n                    , and\n                    <jats:italic>SETD2<\/jats:italic>\n                    ) were more frequently altered in patients who developed BCR in exploratory analyses. Patients harboring alterations in any of these genes (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200996) showed higher pathological T stage, increased BCR rates (27.1% vs. 6.4%), and inferior RFS compared with alteration\u2010negative patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009218;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In multivariate analysis, the presence of these alterations was independently associated with worse RFS. Among individual genes,\n                    <jats:italic>BRCA2<\/jats:italic>\n                    alteration, and particularly\n                    <jats:italic>BRCA2\u2013SETD2<\/jats:italic>\n                    co\u2010alteration, were associated with unfavorable outcomes, although the latter finding was based on a limited number of cases. In patients who developed BCR, alterations were associated with shorter PSA doubling time and poorer outcomes after salvage radiotherapy, particularly in margin\u2010negative cases; however, these subgroup analyses were based on small numbers and should be interpreted as hypothesis\u2010generating. These findings suggest that somatic genomic alterations identified at prostatectomy are associated with early recurrence in localized PC. Further validation in independent cohorts is required to determine whether genomic profiling may contribute to future risk stratification and management strategies.\n                  <\/jats:p>","DOI":"10.1111\/cas.70367","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:50:38Z","timestamp":1773877838000},"page":"1469-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Profiling in Localized Prostate Cancer: Associations With Biochemical Recurrence and Response to Salvage Radiotherapy"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-7364","authenticated-orcid":false,"given":"Kenji","family":"Zennami","sequence":"first","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3008-8078","authenticated-orcid":false,"given":"Tetsuya","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Oncology Innovation Center Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuhisa","family":"Nukaya","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Oncology Innovation Center Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Faculty of Health and Medical Sciences Aichi Syukutoku University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Oncology Innovation Center Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Open Facility Center Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Saya","sequence":"additional","affiliation":[{"name":"Oncology Innovation Center Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Shiroki","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine  Toyoake 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