{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:07:15Z","timestamp":1780387635496,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102020\u2010NR049559"],"award-info":[{"award-number":["RS\u20102020\u2010NR049559"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Melanoma is the most lethal form of skin cancer, with a significantly poor prognosis after metastasis. The BRAF inhibitor dabrafenib increases response rates and overall survival (OS) in advanced\u2010stage melanoma; however, most patients develop resistance rapidly, highlighting the need for improved combination regimens. This study investigated the therapeutic efficacy of JI\u2010CJ002, an herbal extract consisting of\n                    <jats:italic>Angelica gigas<\/jats:italic>\n                    ,\n                    <jats:italic>Aconitum carmichaeli,<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Zingiber officinale<\/jats:italic>\n                    <\/jats:styled-content>\n                    blended in a 2:1:3 (w\/w) ratio, and assessed the combined antineoplastic effects of JI\u2010CJ002 with dabrafenib in melanoma. JI\u2010CJ002 suppressed epithelial\u2013mesenchymal transition (EMT), invasion, and melanin synthesis, and these effects were maintained in combination with dabrafenib. The combination treatment was associated with reduced B7\u2010H3 expression, along with inhibition of signaling pathways implicated in melanoma progression, including JAK2\/STAT3, PI3K\/AKT\/mTOR, and NF\u2010\u03baB. Efficacy of the combination regimen was further evaluated in an A375 xenograft murine model. In\u00a0vivo studies demonstrated that combination therapy reduced tumor volume without causing systemic toxicity, accompanied by decreased proliferation markers (PCNA and Ki\u201067), increased apoptotic marker (cleaved caspase\u20103), and decreased B7\u2010H3 expression in tumor tissues. These results suggest that JI\u2010CJ002 may enhance the antitumor activity of dabrafenib, accompanied by modulation of oncogenic pathways.\n                  <\/jats:p>","DOI":"10.1111\/cas.70387","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:05:30Z","timestamp":1776431130000},"page":"1651-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>JI<\/scp>\n                    \u2010\n                    <scp>CJ002<\/scp>\n                    and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of\n                    <scp>B7<\/scp>\n                    \u2010\n                    <scp>H3<\/scp>"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-4150","authenticated-orcid":false,"given":"Sang\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-8799","authenticated-orcid":false,"given":"Young Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Shin","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-0079","authenticated-orcid":false,"given":"Chunhoo","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-430X","authenticated-orcid":false,"given":"Seong\u2010Gyu","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Korean Medicine\u2010Based Drug Repositioning Cancer Research Center, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735421990078"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.03.943"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-85"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.21.00686"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.05.009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.142206"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406037"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113054"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120709"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188783"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.114"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155267"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26238"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14070530"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.683575"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087528"},{"key":"e_1_2_13_18_1","first-page":"10","article-title":"The Herbal Formula JI017 Induces ER Stress via Nox4 in Breast Cancer Cells","volume":"10","author":"Kim T. 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