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This study investigates its potential anti\u2010tumor mechanism via the enhancement of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010mediated immunity. In murine B16 melanoma and Lewis lung carcinoma models, FJHQ significantly suppressed tumor growth and enhanced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and cytotoxicity. CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell depletion abrogated these effects, confirming their necessity. In\u00a0vitro, FJHQ treatment augmented antigen presentation by tumor cells through upregulation of MHC\u2010I expression, leading to improved CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell recognition and killing. Mechanistically, FJHQ inhibited autophagic flux in tumor cells, as evidenced by mCherry\u2010GFP\u2010LC3 reporter assays and electron microscopy, resulting in impaired lysosomal function and elevated MHC\u2010I levels. Furthermore, combining FJHQ with anti\u2013PD\u20101 therapy synergistically promoted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activity, increased granzyme B and IFN\u2010\u03b3 expression, and induced substantial tumor regression. These findings demonstrate that FJHQ enhances antitumor immunity by suppressing autophagy and elevating MHC\u2010I expression, thereby sensitizing tumors to PD\u20101 blockade. FJHQ represents a promising immunoadjuvant for cancer therapy.\n                  <\/jats:p>","DOI":"10.1111\/cas.70399","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:02:41Z","timestamp":1776841361000},"page":"1778-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autophagy Inhibition by\n                    <i>Fangji Huangqi Decoction<\/i>\n                    Enhances Tumor Immunogenicity and Potentiates\n                    <scp>PD<\/scp>\n                    \u20101 Blockade"],"prefix":"10.1111","volume":"117","author":[{"given":"Yuxiao","family":"Jiang","sequence":"first","affiliation":[{"name":"Research Center of Integrative Medicine, School of Basic Medical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Biochemistry Guangzhou University of Chinese Medicine  Guangzhou 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