{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:16:50Z","timestamp":1788617810390,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pivotal phase 3 trials leading to the approvals of atezolizumab\u2500chemotherapy combinations for non\u2010small cell and extensive\u2010stage small cell lung cancer (NSCLC and ES\u2010SCLC) had strict eligibility criteria. J\u2010TAIL\u20102 was a prospective, observational study in Japan that evaluated atezolizumab regimens for advanced NSCLC\/ES\u2010SCLC, including patients ineligible for global trials. The primary endpoint was 12\u2010month overall survival (OS); safety and efficacy in subgroups defined by age, ECOG PS and\/or G8 score, and creatinine clearance were key secondary endpoints. As of February 3, 2023, 1217 patients were treated in clinical practice based on Japanese labeling\/treatment guidelines. Patients received atezolizumab with either carboplatin and nab\u2010paclitaxel (atezo + CnP), carboplatin\/cisplatin and pemetrexed (atezo + PP), or bevacizumab and carboplatin and paclitaxel (atezo + bev\u2009+\u2009CP) in the NSCLC cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009814) or with carboplatin and etoposide (atezo + CE) in the ES\u2010SCLC cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009403). Overall, 53.5% were \u2265\u200970\u2009years old, and 11.8% had ECOG PS \u2265\u20092; median G8 scores were 13 (NSCLC cohort) and 12 (ES\u2010SCLC). Patients &lt;\u200970 and \u2265\u200970\u2009years had similar median (m)OS and progression\u2010free survival (mPFS) across treatment regimens. Patients with ECOG PS &lt;\u20092 and G8 score \u2265 median had the highest mOS\/PFS vs. patients with ECOG PS \u2265\u20092 and G8 score&lt;median. Patients \u2265\u200970\u2009years had higher incidence of Grade \u2265\u20093 adverse events with atezo + CnP and atezo + PP than patients &lt;\u200970\u2009years; incidences were similar between groups for other regimens. Older vs. younger patients also had higher incidence of interstitial lung disease. Overall, these results suggest that atezolizumab\u2010containing regimens remain effective in older patients, with no new safety signals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    : NCT04501497\n                  <\/jats:p>","DOI":"10.1111\/cas.70411","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:19:59Z","timestamp":1778815199000},"page":"1935-1947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atezolizumab + Chemotherapy in Older Patients With Lung Cancer in Japan"],"prefix":"10.1111","volume":"117","author":[{"given":"Junichi","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of 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