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In our study, we unveiled that CAFs\u2010derived extracellular vesicles (EVs) could deliver miR\u2010375 to endothelial cells (EC) and further contribute to tumor angiogenesis by regulating Ras GTPase Activating Protein 1 (RASA1) in hepatocellular carcinoma (HCC). We also found that HCC patients with more advanced disease showed higher levels of miR\u2010375 in plasma EVs, which were preferentially expressed in the EVs of CAFs. These data provided direct evidence supporting the pivotal role of the tumor suppressor miR\u2010375, which is selectively sorted into CAF\u2010derived EVs, in promoting angiogenesis during HCC progression and revealed that genetically modified CAF\u2010derived EVs may provide a potential therapeutic strategy for HCC. Furthermore, our study indicated that miR\u2010375 in plasma EVs could serve as a potential predictive and prognostic biomarker in HCC patients.<\/jats:p>","DOI":"10.1111\/cas.70422","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T01:10:26Z","timestamp":1779671426000},"page":"2208-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MiR<\/scp>\n                    \u2010375 in\n                    <scp>CAFs<\/scp>\n                    \u2010Derived\n                    <scp>EVs<\/scp>\n                    Promotes\n                    <scp>HCC<\/scp>\n                    Progression via Regulating\n                    <scp>RASA1<\/scp>\n                    and May Potentially Serve as a Biomarker for\n                    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