{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:07:18Z","timestamp":1789240038977,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23EA1033"],"award-info":[{"award-number":["23EA1033"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["26EA0101"],"award-info":[{"award-number":["26EA0101"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Early\u2010onset colorectal cancer (EOCRC) is increasingly described as a rising disease entity, but the descriptive epidemiologic conditions required to interpret that rise remain incompletely articulated. Using Japanese public summary statistics, we conducted a reproducible descriptive epidemiology review to examine whether the observed EOCRC signal is more compatible with substantial detection\u2010related effects, a concurrent increase in invasive burden, or both. We integrated age\u2010group\u2010specific incidence and mortality trends and, where available, decomposed incidence into invasive disease, incidence including in\u00a0situ lesions, and the in\u00a0situ component. Colorectal cancer was the primary case study, and other organized screening\u2010target cancers were used as descriptive contrasts. In Japan, EOCRC showed increasing early\u2010onset\u2010to\u2010older\u2010adult incidence ratios, but these patterns should be interpreted alongside marked in\u00a0situ amplification and limited concordance with mortality. Cross\u2010cancer contrasts further aided interpretation: Unlike CRC, stomach cancer and male lung cancer did not show a comparable early\u2010onset upswing over the 2003\u20132015 comparison window, arguing against a uniform early\u2010onset pattern across screening\u2010target cancers. These descriptive findings are compatible with substantial detection\u2010related effects, but they do not exclude biologic heterogeneity or a concurrent increase in invasive EOCRC. Although public summary statistics cannot establish etiology, they can clarify what current trend data do and do not support. In particular, incidence trends alone are insufficient to justify a true\u2010rise interpretation of clinically significant early\u2010onset colorectal cancer.<\/jats:p>","DOI":"10.1111\/cas.70428","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:13:07Z","timestamp":1780056787000},"page":"2040-2049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interpreting Early\u2010Onset Colorectal Cancer in Japan: A Descriptive Epidemiologic Review Using Public Summary Statistics"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-6314","authenticated-orcid":false,"given":"Keitaro","family":"Matsuo","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center  Nagoya Aichi Japan"},{"name":"Division of Cancer Epidemiology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-4581","authenticated-orcid":false,"given":"Hidemi","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Cancer Information and Control Aichi Cancer Center  Nagoya Aichi Japan"},{"name":"Division of Descriptive Cancer Epidemiology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00426-X"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00600-4"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00441-2"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-025-00670-8"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1371.048"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09025-8"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.048"},{"key":"e_1_2_17_9_1","unstructured":"National Cancer Center Cancer Statistics. 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