{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:11Z","timestamp":1788265451343,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372685"],"award-info":[{"award-number":["82372685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220213"],"award-info":[{"award-number":["2023A1515220213"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite immune checkpoint inhibitors (ICIs) having benefited bladder cancer (BCa) patients, their limited response rates urge elucidation of intrinsic resistance mechanisms. In this study, we demonstrated that ubiquitin conjugating enzyme E2C (UBE2C) promotes the proliferation, invasion, and migration of BCa and inhibits DNA damage, accompanied by a decrease in T cell abundance. In syngeneic C57BL\/6 BCa models and BCa\u2013CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell cocultures, UBE2C silencing reduced CD147 and CTLA\u20104 abundance, restored IFN\u2010\u03b3, TNF\u2010\u03b1, and TGF\u2010\u03b2 secretion, expanded CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    subsets, and attenuated tumor growth, invasion, and migration. Conversely, UBE2C or CD147\/CTLA\u20104 overexpression reinstated T\u2010cell exhaustion and malignant progression. Targeting the UBE2C\u2013CD147\u2013CTLA\u20104 axis resensitizes BCa to immune attack, offering a rational strategy to extend the efficacy of current immunotherapies.\n                  <\/jats:p>","DOI":"10.1111\/cas.70430","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:13:09Z","timestamp":1779934389000},"page":"2366-2378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>UBE<\/scp>\n                    2\n                    <scp>C<\/scp>\n                    \u2010Mediated\n                    <scp>CD<\/scp>\n                    147\u2010\n                    <scp>CTLA<\/scp>\n                    \u20104 Axis Promotes T Cell Exhaustion and Immunosuppressive Microenvironment in Bladder Cancer"],"prefix":"10.1111","volume":"117","author":[{"given":"Xuwei","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Urology Shantou Central Hospital  Shantou China"},{"name":"Shantou Key Laboratory of Basic and Translational Research of Malignant Tumors  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Hong","sequence":"additional","affiliation":[{"name":"Shantou Key Laboratory of Basic and Translational Research of Malignant Tumors  Shantou China"},{"name":"Clinical Medical Research Center Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shantou Key Laboratory of Basic and Translational Research of Malignant Tumors  Shantou China"},{"name":"Clinical Medical Research Center Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixiu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Biobank Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihong","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Oncology Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-1338","authenticated-orcid":false,"given":"Yonghai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Shantou Central Hospital  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.22"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-076743"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.08.010"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010131"},{"key":"e_1_2_13_7_1","article-title":"Predictive Role of Lactylation\u2010Related Gene Signature in the Prognosis and Immunotherapy Response in Bladder Cancer","volume":"97","author":"Liu G.","year":"2025","journal-title":"Archivio Italiano di Urologia e Andrologia"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00689-z"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.12.003"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31250-2"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.01.022"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115792"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.92473"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111696"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179122"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01987-7"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2022.2056"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34156-1"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.09.001"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2332-5"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03800-x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1590"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03939-w"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124441"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-090222-110914"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.216043"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-022-00608-y"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07068-9"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.11.023"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162434"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.765772"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32455-2"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0312-8"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.561"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000450"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00935-4"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1238051"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111803"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12845"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02696-6"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.70430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:02:15Z","timestamp":1788264135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.70430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/cas.70430"],"URL":"https:\/\/doi.org\/10.1111\/cas.70430","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}