{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:09Z","timestamp":1788265449566,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472640"],"award-info":[{"award-number":["81472640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672802"],"award-info":[{"award-number":["81672802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The optimal number of neoadjuvant chemoimmunotherapy cycles for resectable non\u2010small cell lung cancer (NSCLC) remains uncertain. The randomized phase 2 neoSCORE trial (NCT04459611) conducted a comprehensive final analysis, comparing the outcomes of two versus three cycles of neoadjuvant sintilimab combined with platinum\u2010doublet chemotherapy in 60 stage IB\u2013IIIA NSCLC patients, among whom 55 underwent surgery. After a median follow\u2010up period of 56.9\u2009months, no statistically significant differences in disease\u2010free survival (DFS) or overall survival (OS) were observed between the two\u2010cycle and three\u2010cycle groups. Specifically, the 4\u2010year DFS rates stood at 53.8% and 55.2% while the 4\u2010year OS rates were 76.9% and 75.9%, respectively. Major pathological response (MPR) was strongly associated with improved DFS (HR\u2009=\u20090.26, 95% CI: 0.08\u20130.85,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026) and OS (HR\u2009=\u20090.15, 95% CI: 0.03\u20130.81,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028) on multivariable Cox analysis. Exploratory analysis revealed that maintenance immunotherapy was associated with longer DFS among patients who achieved MPR, whereas no clear DFS or OS advantage was observed among patients without MPR. In summary, no superiority of three cycles over two cycles was demonstrated in this study. MPR stands out as an independent prognostic indicator, and maintenance immunotherapy seems to be associated with long\u2010term prognosis in patients who achieved MPR, necessitating further prospective validation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT04459611\n                  <\/jats:p>","DOI":"10.1111\/cas.70442","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:51:03Z","timestamp":1780897863000},"page":"2509-2520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Final Analysis of Neoadjuvant Sintilimab Plus Chemotherapy in\n                    <scp>IB<\/scp>\n                    \u2013\n                    <scp>IIIA<\/scp>\n                    Non\u2010Small\u2010Cell Lung Cancer: Phase 2\n                    <scp>neoSCORE<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6895-8093","authenticated-orcid":false,"given":"Miner","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lufeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine  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