{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:10Z","timestamp":1788265450547,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H03024"],"award-info":[{"award-number":["JP23H03024"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K23368"],"award-info":[{"award-number":["JP24K23368"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K01912"],"award-info":[{"award-number":["JP25K01912"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Boron neutron capture therapy (BNCT) requires selective delivery of boron compounds to tumor cells to achieve therapeutic efficacy. In this study, a BNCT strategy centered on the sodium\u2010dependent multivitamin transporter (SMVT)\u2010targeted biotin\u2010conjugated boron compound, BBCIP, was evaluated, with selective incorporation of p\u2010boronophenylalanine (BPA) according to tumor transporter characteristics. To examine transporter\u2010dependent effects, the CRL1666 metastatic brain tumor model in rats was compared with an F98 glioma model, which exhibits distinct transporter expression profiles. The F98 model is characterized by dominant L\u2010type amino acid transporter 1 (LAT1) expression and low SMVT levels, whereas the CRL1666 model shows relatively high SMVT expression. BBCIP demonstrated stable and quantifiable intratumoral boron pharmacokinetics in both models. In BNCT experiments, BBCIP alone showed limited therapeutic efficacy in the LAT1\u2010dominant F98 model (median survival, 29 vs. 23\u2009days in controls), whereas survival was further improved with the addition of BPA. In contrast, in the SMVT\u2010high CRL1666 model, BBCIP\u2010based BNCT significantly prolonged survival (30 vs. 15.5\u2009days in controls), with only modest additional benefit from BPA. These findings indicate that the therapeutic contribution of BBCIP\u2010based BNCT depends on tumor transporter expression and that BPA may be advantageous in tumors with low SMVT expression. Rather than relying on a single boron carrier, these findings support a biology\u2010driven strategy in which boron agents are selected and combined according to tumor\u2010specific characteristics.<\/jats:p>","DOI":"10.1111\/cas.70444","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:56:24Z","timestamp":1781175384000},"page":"2555-2566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transporter\u2010Associated Therapeutic Efficacy of an\n                    <scp>SMVT<\/scp>\n                    \u2010Targeted Boron Carrier in Boron Neutron Capture Therapy"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2869-3485","authenticated-orcid":false,"given":"Kenichiro","family":"Eza","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Osaka Medical and Pharmaceutical University  Takatsuki Osaka 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