{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:07Z","timestamp":1788265447666,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nedaplatin is a second\u2010generation platinum compound with reduced nephrotoxicity compared with cisplatin. Given its favorable tolerability in advanced non\u2010small cell lung cancer (NSCLC), we prospectively evaluated the tolerability and efficacy of an adjuvant nedaplatin plus docetaxel chemotherapy regimen in patients with completely resected NSCLC. Patients with stage IB\u2013IIIA NSCLC who had undergone complete surgical resection received nedaplatin (80\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) and docetaxel (60\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) intravenously on day 1 once every 4\u2009weeks for up to four cycles. The primary endpoint was treatment tolerability, defined as completion of the planned four cycles, and compared with historical data for the standard cisplatin plus vinorelbine regimen. The secondary endpoint was efficacy, determined by relapse\u2010free survival (RFS) after surgery. Thirty\u2010five patients were enrolled, with median age of 65\u2009years (range, 36\u201377\u2009years). Adenocarcinoma (57.1%) and stage II disease (60.0%) were most common. Dose reductions were needed in some patients, however, 74.3% of patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926) completed all four cycles, meeting the primary endpoint. Grade 3 or 4 neutropenia and anorexia occurred in 67.8% and 9.0% of patients, respectively. No grade 3 or 4 renal dysfunction was noted. Concerning efficacy, the median RFS time was 63\u2009months (95% confidence interval [CI], 20\u2013NE), and the 5\u2010year overall survival rate was 85.7% (95% CI, 70.0\u201393.9). Long\u2010term retrospective follow\u2010up (median: 119\u2009months) showed that the 10\u2010year RFS rate was 52.9% (95% CI, 36.1\u201369.1). These results indicate that adjuvant chemotherapy with nedaplatin plus docetaxel is tolerable and effective in patients with completely resected NSCLC.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    UMIN number: 000004634\n                  <\/jats:p>","DOI":"10.1111\/cas.70446","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:31:11Z","timestamp":1781317871000},"page":"2535-2542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Trial on Tolerability and Efficacy of Adjuvant Nedaplatin Plus Docetaxel for Non\u2010Small Cell Lung Cancer"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-2691","authenticated-orcid":false,"given":"Koji","family":"Teramoto","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Shiga University of Medical Science  Otsu Shiga Japan"},{"name":"Center for Advanced Medicine Against Cancer Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kaku","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shiga University of Medical Science Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shiga University of Medical Science Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-0524","authenticated-orcid":false,"given":"Masayuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shiga University of Medical Science Shiga University of Medical Science  Otsu Shiga 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