{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:50:52Z","timestamp":1792522252711,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A04J1823"],"award-info":[{"award-number":["2023A04J1823"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A04J5206"],"award-info":[{"award-number":["2024A04J5206"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cuproptosis, a copper\u2010dependent form of regulated cell death, has been documented in colorectal cancer (CRC), yet its impact on the tumor immune microenvironment remains incompletely understood. Here, we demonstrate that elesclomol\u2010induced cuproptosis potently activates innate and adaptive antitumor immunity, markedly enhancing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell cytotoxicity while attenuating exhaustion. Mechanistically, FDX1, which correlates inversely with CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and predicts poor prognosis, functions as a core regulator of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell functionality during cuproptosis. FDX1 promotes CRC proliferation and metastasis while suppressing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell cytokine production. We further show that FDX1 binds DICER1 to reduce DMBT1 mRNA stability, with FDX1 and DMBT1 expression exhibiting significant negative correlation in CRC tissues. Our findings establish the FDX1\u2013DICER1\u2013DMBT1 axis as a critical regulator of CRC progression and immune evasion, suggesting that therapeutic targeting of this pathway could enhance antitumor immunity and overcome resistance to existing immunotherapies.\n                  <\/jats:p>","DOI":"10.1111\/cas.70457","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:52:33Z","timestamp":1782478353000},"page":"2659-2675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>FDX1<\/scp>\n                    Depletion Activates\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T Cell Antitumor Immunity by Promoting\n                    <scp>DMBT1<\/scp>\n                    Secretion in Cuproptosis of Colorectal Cancer"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4104-4227","authenticated-orcid":false,"given":"Jieqiong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology Nanfang Hospital, Southern Medical University  Guangzhou Guangdong China"},{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Province Key Laboratory of Molecular Tumor Pathology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaixi","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanfang Hospital, Southern Medical University  Guangzhou Guangdong China"},{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University  Guangzhou Guangdong China"},{"name":"Guangdong Province Key Laboratory of Molecular Tumor Pathology  Guangzhou Guangdong 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