{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:53:18Z","timestamp":1790931198208,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008886","name":"Princess Takamatsu Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07620"],"award-info":[{"award-number":["20K07620"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02750"],"award-info":[{"award-number":["23H02750"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K02279"],"award-info":[{"award-number":["26K02279"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cationic amino acid transporters (CATs), encoded by the SLC7A family, play essential roles in the uptake of arginine and other cationic amino acids, thereby regulating cellular metabolism, signaling, and immune responses. Among SLC7A transporters, SLC7A1\u20134 constitute the classical CAT family and have emerged as important regulators of tumor biology. Arginine is increasingly recognized as a critical metabolic resource within the tumor microenvironment. Consequently, dysregulated CAT expression can affect both cancer cell fitness and tumor\u2013immune interactions. In this review, we summarize current knowledge regarding the biological and pathological roles of SLC7A1\u20134 in cancer. SLC7A1 is broadly associated with enhanced tumor growth, metabolic adaptation, and therapeutic resistance through increased arginine uptake. In contrast, SLC7A2 exhibits context\u2010dependent functions, displaying both tumor\u2010promoting and tumor\u2010suppressive activities depending on tumor type and immune context regulation. Emerging evidence also implicates SLC7A3 in metastatic progression through transcriptional programs that increase arginine availability, whereas the physiological role of SLC7A4 remains largely unresolved. Despite its structural similarity to other CAT family members, convincing evidence for its membrane localization, cationic amino acid transport activity, and cancer\u2010associated functions is still lacking. We further discuss the mechanistic pathways linking CAT to cancer progression and tumor\u2013immune metabolic competition. Finally, we highlight key unresolved questions, including functional redundancy among CAT family members, context\u2010dependent biological effects, and the uncertain role of SLC7A4. A deeper understanding of CAT biology may provide new opportunities for therapeutic strategies targeting amino acid metabolism in cancer.<\/jats:p>","DOI":"10.1111\/cas.70468","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:00:09Z","timestamp":1783918809000},"page":"2636-2643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Pathological Roles of Cationic Amino Acid Transporters (\n                    <scp>CATs<\/scp>\n                    ) in Cancer"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8664-3462","authenticated-orcid":false,"given":"Thant Thant","family":"Myo Oo","sequence":"first","affiliation":[{"name":"Institute for Advanced Biosciences Keio University  Tsuruoka Japan"},{"name":"School of Health Sciences IMU University  Kuala Lumpur 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