{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:01:23Z","timestamp":1784624483794,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302840"],"award-info":[{"award-number":["81302840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Eastern China malignant mesothelioma (MM) presents distinct features\u2013younger age, female predominance, and moremalignant peritoneal mesothelioma (MPeM)\u2013contrasting with the Western profile of older males with malignant pleural mesothelioma (MPM). Robust survival data for this population are still unavailable. This retrospective study included 253\u2009MM patients from Zhejiang Cancer Hospital (2010\u20132024; 222 from Zhejiang Province, ZJ cohort) to update regional epidemiology and compare survival with the Surveillance, Epidemiology, and End Results program (SEER). The ZJ cohort exhibited a younger median age at diagnosis (58 vs. 74\u2009years), a higher proportion of females (62% vs. 24%), and a higher prevalence of MPeM (54% vs. 11%) relative to the SEER cohort. Overall survival (OS) was significantly prolonged in the ZJ cohort (median OS: 22 vs. 10\u2009months), with survival benefits consistently observed across sex, age, and MPM subgroups. Multivariate Cox analysis revealed age as the only consistent independent prognostic factor in both ZJ and SEER cohorts. Following propensity score matching to minimize confounding, the ZJ cohort maintained a significantly longer survival in MPM but exhibited worse outcome in MPeM relative to SEER. Collectively, this study not only updated epidemiologic features for MM in Eastern China but also reported the unique survival patterns, uncovering inter\u2010population heterogeneity. These findings emphasize the value of region\u2010specific prognostic evidence and the limitations of directly applying Western data to Asian populations.<\/jats:p>","DOI":"10.1111\/cas.70481","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:04:38Z","timestamp":1784621078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological and Prognostic Differences in Malignant Mesothelioma Between Eastern China and\n                    <scp>SEER<\/scp>\n                    Database"],"prefix":"10.1111","author":[{"given":"Ningning","family":"Li","sequence":"first","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruting","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulei","family":"Shao","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Zhejiang Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanai","family":"Bao","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Mao","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-9671","authenticated-orcid":false,"given":"Zhongjian","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040685","article-title":"Cytoskeletal Organization Correlates to Motility and Invasiveness of Malignant Mesothelioma Cells","volume":"13","author":"Keller M.","year":"2021","journal-title":"Cancers"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"402","article-title":"Mesothelioma: Scientific Clues for Prevention, Diagnosis, and Therapy","volume":"69","author":"Carbone M.","year":"2019","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"10","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ng.912","article-title":"Germline BAP1 Mutations Predispose to Malignant Mesothelioma","volume":"43","author":"Testa J. R.","year":"2011","journal-title":"Nature Genetics"},{"issue":"4","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1158\/2767-9764.CRC-23-0423","article-title":"Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1\u2010Mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment","volume":"4","author":"Kadariya Y.","year":"2024","journal-title":"Cancer Research Communications"},{"issue":"15","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/onc.2015.243","article-title":"Minimal Asbestos Exposure in Germline BAP1 Heterozygous Mice Is Associated With Deregulated Inflammatory Response and Increased Risk of Mesothelioma","volume":"35","author":"Napolitano A.","year":"2016","journal-title":"Oncogene"},{"issue":"52","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"33466","DOI":"10.1073\/pnas.2019652117","article-title":"Heterozygous Germline BLM Mutations Increase Susceptibility to Asbestos and Mesothelioma","volume":"117","author":"Bononi A.","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"29","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2405231121","article-title":"Germline BARD1 Variants Predispose to Mesothelioma by Impairing DNA Repair and Calcium Signaling","volume":"121","author":"Novelli F.","year":"2024","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"21","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1016\/j.cub.2017.09.007","article-title":"Long\u2010Fiber Carbon Nanotubes Replicate Asbestos\u2010Induced Mesothelioma With Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a\/Arf)","volume":"27","author":"Chernova T.","year":"2017","journal-title":"Current Biology"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"4","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.21037\/jtd-24-1778","article-title":"A Bibliometric Analysis of Malignant Pleural Mesothelioma From 2010 to 2023","volume":"17","author":"Chen S.","year":"2025","journal-title":"Journal of Thoracic Disease"},{"issue":"3","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1111\/1759-7714.15533","article-title":"A Multi\u2010Center Real\u2010World Study of Clinicopathologic Characteristics and Efficacy of the Malignant Mesothelioma in Chinese Population","volume":"16","author":"Sun C.","year":"2025","journal-title":"Thoracic Cancer"},{"issue":"4","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/jamaoncol.2016.5487","article-title":"Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China","volume":"3","author":"Mao W.","year":"2017","journal-title":"JAMA Oncology"},{"issue":"6","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jtho.2023.01.095","article-title":"Global Incidence, Risk Factors, and Temporal Trends of Mesothelioma: A Population\u2010Based Study","volume":"18","author":"Huang J.","year":"2023","journal-title":"Journal of Thoracic Oncology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1172496","article-title":"The Incidence of Malignancies in Asbestosis With Chrysotile Exposure: A Large Chinese Prospective Cohort Study","volume":"13","author":"Wang J.","year":"2023","journal-title":"Frontiers in Oncology"},{"issue":"3","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jncc.2024.05.003","article-title":"Burden of Malignant Mesothelioma in China During 1990\u20102019 and the Projections Through 2029","volume":"4","author":"Huang Q.","year":"2024","journal-title":"Journal of the National Cancer Center"},{"issue":"18","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.18632\/oncotarget.4414","article-title":"Distinctive Clinical Characteristics of Malignant Mesothelioma in Young Patients","volume":"6","author":"Thomas A.","year":"2015","journal-title":"Oncotarget"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jss.2025.05.022","article-title":"Different Diseases, Different Outcomes: A Comparative Study of Peritoneal and Pleural Subtypes","volume":"312","author":"Boutros C. 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C.","year":"2008","journal-title":"Environmental Health Perspectives"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.70481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:04:42Z","timestamp":1784621082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.70481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":28,"alternative-id":["10.1111\/cas.70481"],"URL":"https:\/\/doi.org\/10.1111\/cas.70481","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2025-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cas.70481"}}