{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:11:28Z","timestamp":1788621088562,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z231100007223002"],"award-info":[{"award-number":["Z231100007223002"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Photodynamic therapy (PDT) is a localized treatment for esophageal stenosis and dysphagia in advanced cancer. This study evaluated the efficacy and safety of Cosiporfin sodium (DVDMS)\u2010mediated PDT for dysphagia in advanced esophageal cancer. In this Phase II trial, patients with advanced esophageal cancer and Grade \u2265\u20092 dysphagia, who were unsuitable for or declined curative therapies, received 0.2\u2009mg\/kg DVDMS followed by PDT (wavelength: 630\u2009nm) at varying regimens: 102\u2009J\/cm (24\u2009h post\u2010injection), 200\u2009J\/cm (24\u2009h), and 150\u2009J\/cm (18\u2009h). Safety was the primary endpoint. The study enrolled 20 patients in the 102\u2009J\/cm 24\u2009h group, 6 in the 200\u2009J\/cm 24\u2009h group, and 4 in the 150\u2009J\/cm 18\u2009h group. Two patients experienced dose\u2010limiting toxicities: One upper abdominal pain (16.7%) in the 200\u2009J\/cm 24\u2009h group and one non\u2010cardiac chest pain (25.0%) in the 150\u2009J\/cm 18\u2009h group. Common adverse events included non\u2010cardiac chest pain (10.0%) related to DVDMS and non\u2010cardiac chest pain (20.0%) and anemia (20.0%) related to PDT. The photosensitivity test showed that by day 4, 66.7% of patients tested negative, improving to 86.7% by day 7, and all patients were negative by day 28. The esophageal overall response rate was 40.0% on day 28. The median duration of esophageal response and median OS for all patients were 4.86\u2009months (95% CI: 1.51\u20135.32) and 9.51\u2009months (95% CI: 5.45\u2013NE), respectively. DVDMS\u2010mediated PDT demonstrates acceptable safety and sustained efficacy in improving esophageal stenosis and dysphagia in advanced esophageal cancer.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/chictr.org.cn\">chictr.org.cn<\/jats:ext-link>\n                    ChiCTR2000032829.\n                  <\/jats:p>","DOI":"10.1111\/cas.70507","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:15:31Z","timestamp":1788617731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <scp>DVDMS<\/scp>\n                    \u2010Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase\n                    <scp>II<\/scp>\n                    Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3919-7996","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shegan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-0877","authenticated-orcid":false,"given":"Yongqian","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Yichun People's Hospital  Yichun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshuo","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanyou","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingting","family":"Song","sequence":"additional","affiliation":[{"name":"Shanghai Guangsheng Pharmaceutical Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baobao","family":"Xin","sequence":"additional","affiliation":[{"name":"Shanghai Guangsheng Pharmaceutical Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Guangsheng Pharmaceutical Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-4756","authenticated-orcid":false,"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.10.012"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12215"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010022\u201012945\u20108"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S362759"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1024576"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2017.09.003"},{"issue":"6","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0016-5107(95)70002-1","article-title":"Photodynamic Therapy With Porfimer Sodium Versus Thermal Ablation Therapy With Nd:YAG Laser for Palliation of Esophageal Cancer: A Multicenter Randomized Trial","volume":"42","author":"Lightdale C. J.","year":"1995","journal-title":"Gastrointestinal Endoscopy"},{"key":"e_1_2_13_9_1","unstructured":"U.S. Food and Drug Administration Prescribing information for PHOTOFRIN 1995Available from https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/020451s029 021525s005lbl.pdf."},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132785"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00019"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010112"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19950601)75:11"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910630209"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13171"},{"issue":"1","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0016-5085(95)90269-4","article-title":"Photodynamic Therapy for Obstructing Esophageal Cancer: Light Dosimetry and Randomized Comparison With Nd:YAG Laser Therapy","volume":"109","author":"Heier S. K.","year":"1995","journal-title":"Gastroenterology"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta14370"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13190"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010018\u20100140\u2010z"},{"issue":"5","key":"e_1_2_13_20_1","first-page":"241","article-title":"Consensus on Efficacy Evaluation Criteria for Photodynamic Therapy in Tumors 2014 (First Edition) (In Chinese)","volume":"23","author":"C.E.C.o.T.P. Therapy","year":"2014","journal-title":"Chinese Journal of Laser Medicine & Surgery"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820930335"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.06.002"},{"issue":"1","key":"e_1_2_13_23_1","first-page":"27","article-title":"Effect of Photodynamic Therapy and Stent on the Management of Advanced Esophageal Cancer","volume":"23","author":"Weihong S.","year":"2006","journal-title":"Chinese Journal of Digestive Endoscopy"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14029"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43046\u2010021\u201000093\u20101"},{"issue":"5","key":"e_1_2_13_26_1","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1136\/gut.50.suppl_5.v1","article-title":"Guidelines for the Management of Oesophageal and Gastric Cancer","volume":"50","author":"Allum W. H.","year":"2002","journal-title":"Gut"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0019"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.70507","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:15:33Z","timestamp":1788617733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.70507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":26,"alternative-id":["10.1111\/cas.70507"],"URL":"https:\/\/doi.org\/10.1111\/cas.70507","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cas.70507"}}