{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:27:01Z","timestamp":1787218021228,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Historically, information on routes of diagnosis in cancer registration in Japan lacked reliability. The launch of the National Cancer Registry in 2016 produced a marked improvement in data accuracy. In this study, we aimed to estimate the proportion of screen\u2010detected gastrointestinal cancers using the National Cancer Registry and to examine its correlation with cancer screening participation rates. We analyzed 2016\u20132020 National Cancer Registry data to identify screen\u2010detected gastrointestinal cancers and assess the correlation between route of diagnosis and stage at diagnosis. Screening participation rates were extracted from the Comprehensive Survey of Living Conditions (CSLC) and the Report on Regional Public Health Services and Health Promotion Services via e\u2010Stat, and their correlations with screen\u2010detected cancer proportions were assessed using prefecture\u2010level data. Screen\u2010detected cancers accounted for 14.4% for esophageal cancer, 18.6% for gastric cancer, and 21.3% for colorectal cancer. Cancers detected through \u201cother routes (including symptomatic detection)\u201d accounted for 47.1%, 41.6%, and 45.1%, respectively. Screen\u2010detected cases more frequently presented as intraepithelial or localized disease. In gastric and colorectal cancer, positive correlations were observed between the proportions of screen\u2010detected cancers and screening participation rates; for example, correlation coefficients based on the 2019 CSLC were 0.61 for gastric cancer and 0.71 for colorectal cancer. Screen\u2010detected gastrointestinal cancers accounted for roughly 20% of all detected routes. Higher screening rates were correlated with higher proportions of screen\u2010detected cancers. These findings suggest that the proportion of screen\u2010detected cancers may serve as an indicator of screening program quality.<\/jats:p>","DOI":"10.1111\/cas.70509","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:05:59Z","timestamp":1787216759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proportion of Screen\u2010Detected Gastrointestinal Cancers From the National Cancer Registry in Japan"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3422-9676","authenticated-orcid":false,"given":"Ryuji","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East  Kashiwa Japan"},{"name":"Division of Epidemiology National Cancer Center Institute for Cancer Control  Tokyo Japan"},{"name":"Course of Advanced Clinical Research Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-5751","authenticated-orcid":false,"given":"Yukai","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Cohort Research National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-4295","authenticated-orcid":false,"given":"Taisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Health Services Research, Institute for Cancer Control National Cancer Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-5096","authenticated-orcid":false,"given":"Tomio","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Division of Screening Assessment and Management National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Shinmura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-1449","authenticated-orcid":false,"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East  Kashiwa Japan"},{"name":"Course of Advanced Clinical Research Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Division of Science and Technology for Endoscopy, Exploratory Oncology Research and Clinical Trial Center National Cancer Center  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-4131","authenticated-orcid":false,"given":"Motoki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Division of Epidemiology National Cancer Center Institute for Cancer Control  Tokyo Japan"},{"name":"Division of Cohort Research National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12835"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100741"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079088"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.11.286"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300720"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00084\u2010X"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00199\u20106"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9412"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100458"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.11236\/jph.23\u2010107"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010014\u20100765\u20104"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010008\u20100759\u20101"},{"issue":"4","key":"e_1_2_13_14_1","first-page":"389","article-title":"Legislation of Cancer Registries in Japan\u2010 An Outline of the National Cancer Registry","volume":"42","author":"Nishino Y.","year":"2015","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.11.033"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.11.032"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu003"},{"issue":"1","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2342\/ymj.68.31","article-title":"Importance of Cancer Screening Check\u2010 Up Encouragement to Senior Citizens After Retirement~Based on Analysis of Yamaguchi Prefecture Cancer Registration","volume":"68","author":"Sunakawa H.","year":"2019","journal-title":"Yamaguchi Rinsho Igak"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/09691413241240564"},{"key":"e_1_2_13_20_1","unstructured":"e\u2010Stat \u201cGeneral Potal of Governmental Statistics (Japanese) \u201daccessed February 15 2024 https:\/\/www.e\u2010stat.go.jp\/."},{"issue":"5","key":"e_1_2_13_21_1","first-page":"556","article-title":"Target Age Group for Intensive Colorectal Cancer Screening\u2014Discussion Based on Survival Rate and Expected Years of Life","volume":"52","author":"Shimada T.","year":"2014","journal-title":"Journal of Gastrointestinal Cancer Screening"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u20100883\u2010x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20240090"}],"container-title":["Cancer 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