{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:04:53Z","timestamp":1790661893628,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    As a T\u2010cell receptor co\u2010stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells, B cells, natural killer cells (NK cells), and tumor cells. To date, the biological functions and clinical significance of SLAMF6 in certain solid tumors remain to be elucidated. We analyzed the transcriptional expression pattern of SLAMF6 and its relationship with clinical outcomes using clinical specimens and pancancer databases. Next, multispectral immunofluorescence was applied to assess the correlation between SLAMF6 expression and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell activation and infiltration in clinical samples, with additional validation through immune\u2010infiltration analysis. In parallel, using a colorectal cancer xenograft model, we examined how upregulation of SLAMF6 combined with immune\u2010checkpoint blockade (anti\u2010PD\u2010L1) influences immunotherapy efficacy. Ultimately, our findings indicate that SLAMF6 modulates CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell activation and infiltration through the STAT1\/CXCL10 axis, thereby enhancing the recruitment of these effector cells to tumor sites.\n                  <\/jats:p>","DOI":"10.1111\/cas.70530","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:33Z","timestamp":1790660793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SLAMF6<\/scp>\n                    Enhances the Efficacy of Anti\u2010\n                    <scp>PD<\/scp>\n                    \u2010\n                    <scp>L1<\/scp>\n                    Immunotherapy in\n                    <scp>CRC<\/scp>\n                    Through the\n                    <scp>STAT1<\/scp>\n                    \/\n                    <scp>CXCL10<\/scp>\n                    Signaling Axis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3673-3852","authenticated-orcid":false,"given":"Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jiangsu Province (Suqian) Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-3971","authenticated-orcid":false,"given":"Xudong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"6","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.ccell.2023.04.011","article-title":"Remodeling of the Immune and Stromal Cell Compartment by PD\u20101 Blockade in Mismatch Repair\u2010Deficient Colorectal Cancer","volume":"41","author":"Li 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