{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:00:05Z","timestamp":1790748005319,"version":"4.1.0"},"reference-count":119,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress\u2010responsive translational reprogramming hub in cancer. This review synthesizes recent paradigm shifts that redefine PABPC1 function: From global translation maintenance to selective oncogenic mRNA amplification via liquid\u2013liquid phase separation; from binary protein\u2010RNA interactions to complex regulatory networks involving lncRNAs and circRNAs that modulate PABPC1 stability, localization, and target selectivity; and from diffuse cytoplasmic distribution to functionally compartmentalized condensates. PABPC1 integrates diverse post\u2010translational modifications, including SUMOylation, acetylation, and ubiquitination, that enable stress adaptation, and actively regulates alternative polyadenylation to influence 3\u2032UTR length and gene expression. Positioned at the convergence point of multiple oncogenic signaling pathways (PI3K\/AKT, Wnt\/\u03b2\u2010catenin, NF\u2010\u03baB, and etc.), PABPC1 converts upstream signals into translational outputs that drive tumor progression, metastasis, and therapy resistance across malignancies. Its functional duality, context\u2010dependent activities, and paralog\u2010specific roles underscore both the complexity and therapeutic potential of targeting this multifaceted RNA\u2010binding protein.<\/jats:p>","DOI":"10.1111\/cas.70549","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:35:32Z","timestamp":1790746532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>PABPC1<\/scp>\n                    in Cancer: From a Translational Housekeeper to a Stress\u2010Responsive Regulatory Hub"],"prefix":"10.1111","author":[{"given":"Cuiwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology The Affiliated Hospital of Southwest Medical University  Luzhou Sichuan China"},{"name":"Luzhou Key Laboratory of Precision Pathology Diagnosis for Serious Diseases  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated Hospital of Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-685X","authenticated-orcid":false,"given":"Wenbo","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated Hospital of Southwest Medical University  Luzhou Sichuan China"},{"name":"Luzhou Key Laboratory of Precision Pathology Diagnosis for Serious Diseases  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1093\/nar\/15.12.4771","article-title":"Human mRNA Polyadenylate\u2010Binding Protein: Evolutionary Conservation of a Nucleic Acid Binding Motif","volume":"15","author":"Grange T.","year":"1987","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_16_3_1","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1038\/s41467-026-69639-y","article-title":"PAN2 Maintains mRNA Poly(A): Tail Homeostasis and Regulates Translation During Spermiogenesis in Mice","volume":"17","author":"Wu X.","year":"2026","journal-title":"Nature Communications"},{"key":"e_1_2_16_4_1","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1038\/s41467-025-62741-7","article-title":"Multivalent Interactions With CCR4\u2010NOT and PABPC1 Determine mRNA Repression Efficiency by Tristetraprolin","volume":"16","author":"Pekovic F.","year":"2025","journal-title":"Nature Communications"},{"key":"e_1_2_16_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153517","article-title":"The Divergent LARP1 PAM2 Motif Adopts a Non\u2010Canonical Conformation for MLLE Binding","volume":"810","author":"Behvarmanesh A.","year":"2026","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"e_1_2_16_6_1","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1038\/s44318-026-00765-5","article-title":"Global Stabilization of the Transcriptome in Mitotic Cells","volume":"45","author":"Khalizeva E.","year":"2026","journal-title":"EMBO Journal"},{"key":"e_1_2_16_7_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1101\/gad.1262905","article-title":"Mammalian Poly(A):\u2010Binding Protein Is a Eukaryotic Translation Initiation Factor","volume":"19","author":"Kahvejian A.","year":"2005","journal-title":"Genes & Development"},{"key":"e_1_2_16_8_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/wrna.1151","article-title":"Poly(A): Binding Proteins: Are They All Created Equal?","volume":"4","author":"Goss D. 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