{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:52:53Z","timestamp":1791895973221,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH193"],"award-info":[{"award-number":["ZR2022MH193"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600078"],"award-info":[{"award-number":["81600078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Noncoding RNAs, including circular RNAs (circRNAs), have been demonstrated to play vital roles in tumorigenesis. Uncovering the functions of circRNAs in tumorigenesis and their underlying regulatory mechanisms may suggest new approaches to the development of novel diagnostic and therapeutic strategies for human cancer. Here we report the important role of hsa_circ\u20100080018 in diffuse large B\u2010cell lymphoma (DLBCL) progression and the potential impact of hsa_circ\u20100080018 in DLBCL tumorigenesis. Hsa_circ\u20100080018 was evidently upregulated in newly diagnosed DLBCL patient plasma, and as a reference to classify GCB and non\u2010GCB subtypes. The high expression of hsa_circ\u20100080018 also appeared in plasma exosome and can transport to tumor microenvironment (TME). In addition, we found that at the molecular level hsa_circ\u20100080018 acted as a decoy for miR\u2010625\u20105p and regulated tumor associated macrophage (TAM) polarization by suppressing miR\u2010625\u20105p that led to IGF\u20101\/IGF\u20101R pathway activation. The activated IGF\u20101\/IGF\u20101R pressed macrophage polarizing to M2 and ultimately promoted tumor progression. Our results provided a new potential biomarker in DLBCL plasma that is correlated with cell of origin (COO). The mechanism of circ\u20100080018 in tumor progression was plasma generated circ\u20100080018 delivered to TME by exosome and pushed macrophage polarization. Our research may provide a new target for the DLBCL treatment and prognosis in future.<\/jats:p>","DOI":"10.1111\/cas.70554","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:29:25Z","timestamp":1791894565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Plasma Biomarker\n                    <scp>hsa_circ_0080018<\/scp>\n                    Drives\n                    <scp>DLBCL<\/scp>\n                    Progression via\n                    <scp>M2<\/scp>\n                    Polarization of Tumor\u2010Associated Macrophages"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-5485","authenticated-orcid":false,"given":"Yanfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology Key Laboratory of Cancer Prevention and Therapy Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute &amp; Hospital, National Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164\u2010021\u201000208\u20103"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201009\u20100113"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201011\u2010764332"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2015.32"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.01.011"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.361"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010019\u20100594\u20106"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2021.2023863"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258\u2010021\u201001094\u2010z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010021\u201001458\u20109"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000001366"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102122"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8586354"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.014"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003871"},{"issue":"3","key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1083\/jcb.101.3.942","article-title":"Electron Microscopic Evidence for Externalization of the Transferrin Receptor in Vesicular Form in Sheep Reticulocytes","volume":"101","author":"Pan B. 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