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Besides toxicity in peritoneal macrophages, the compounds exhibited a significant leishmanicidal activity. Of twelve compounds tested, five showed a strong leishmanicidal activity against promastigote forms of <jats:italic>Leishmania amazonensis<\/jats:italic> and <jats:italic>L.\u00a0braziliensis<\/jats:italic> with IC<jats:sub>50<\/jats:sub> below 10\u2003\u03bc<jats:sc>m<\/jats:sc>. Compounds <jats:bold>11<\/jats:bold>, <jats:bold>14<\/jats:bold>, <jats:bold>15,<\/jats:bold> and <jats:bold>16<\/jats:bold> showed a strong leishmanicidal activity on intracellular amastigotes (IC<jats:sub>50<\/jats:sub> values of 2.78; 0.27; 1.03, and 1.33\u2003\u03bc<jats:sc>m<\/jats:sc>, respectively), which is unlikely to be owing to the activation of nitric oxide production by macrophages.<\/jats:p>","DOI":"10.1111\/cbdd.12017","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T14:48:01Z","timestamp":1344437281000},"page":"745-751","source":"Crossref","is-referenced-by-count":16,"title":["Effect of 3\u2010Alkylpyridine Marine Alkaloid Analogues in <i>Leishmania<\/i> Species Related to American Cutaneous Leishmaniasis"],"prefix":"10.1111","volume":"80","author":[{"given":"Patr\u00edcia A.","family":"Machado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviane F.","family":"Hil\u00e1rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidiane O.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana L. 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