{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:21Z","timestamp":1787013981084,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    This theoretical and experimental study describes the design and evaluation of the free\u2010radical scavenging effect for the molecular association of 4\u2010aminophenol and salicylate derivatives. For this purpose, we employed theoretical methods for the selection of antioxidant drugs and the rapid methods of evaluation: the 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl radical and the thiobarbituric acid reactive substances in the lipid peroxidation initiated by Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and ascorbic acid in human erythrocytes. The associate derivatives exhibited a more potent inhibition than the salicylic acid, while the benzoyl compound exhibited a more potent inhibition than paracetamol. The molecular parameters related to the electron distribution and structure (ionization potential and energy of the highest occupied molecular orbital) correlated very well with the antioxidant action of the compounds studied here in different tests.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.12096","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T09:28:28Z","timestamp":1360747708000},"page":"414-419","source":"Crossref","is-referenced-by-count":26,"title":["Design and Evaluation of 4\u2010Aminophenol and Salicylate Derivatives as Free\u2010Radical Scavenger"],"prefix":"10.1111","volume":"81","author":[{"given":"Rosivaldo S.","family":"Borges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gla\u00e9cia A. N.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce K. 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