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Occasionally, it may switch to lytic infection. Latent EBV infection has been associated with several diseases, such as <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>urkitt lymphoma (BL). To date, there are no available drugs to target latent <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>, and the existing broad\u2010spectrum antiviral drugs are mainly active against lytic viral infection. Thus, using computational molecular docking, a virtual screen of a library of small molecules, including xanthones and flavonoids (described with potential for antiviral activity against EBV), was carried out targeting EBV proteins. The more interesting molecules were selected for further computational analysis, and sub\u2010sequently, the compounds were tested in the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>aji (BL) cell line, to evaluate their activity against latent EBV. This work identified three novel sulfated small molecules capable of decreasing EBV levels in a BL. Therefore, the <jats:italic>in silico<\/jats:italic> screening presents a good approach for the development of new anti\u2010<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> agents.<\/jats:p>","DOI":"10.1111\/cbdd.12109","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T08:37:31Z","timestamp":1359189451000},"page":"631-644","source":"Crossref","is-referenced-by-count":12,"title":["Sulfated Small Molecules Targeting <scp>EBV<\/scp> in <scp>B<\/scp>urkitt Lymphoma: From <i>In Silico<\/i> Screening to the Evidence of <i>In Vitro<\/i> Effect on Viral Episomal <scp>DNA<\/scp>"],"prefix":"10.1111","volume":"81","author":[{"given":"Raquel T.","family":"Lima","sequence":"first","affiliation":[{"name":"Cancer Drug Resistance Group IPATIMUP \u2013 Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal"},{"name":"CEQUIMED\u2010UP Centre of Medicinal Chemistry \u2013 University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Seca","sequence":"additional","affiliation":[{"name":"Cancer Drug Resistance Group IPATIMUP \u2013 Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal"},{"name":"Department of Biological Sciences Laboratory of Microbiology Faculty of Pharmacy University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Palmeira","sequence":"additional","affiliation":[{"name":"Cancer Drug Resistance Group IPATIMUP \u2013 Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal"},{"name":"CEQUIMED\u2010UP Centre of Medicinal Chemistry \u2013 University of Porto Porto Portugal"},{"name":"Departamento de Ci\u00eancias Qu\u00edmicas Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica Faculdade de Farm\u00e1cia Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel X.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica da Madeira Centro de Compet\u00eancia de Ci\u00eancias Exactas e da Engenharia University of Madeira Funchal Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Castro","sequence":"additional","affiliation":[{"name":"CEQUIMED\u2010UP Centre of Medicinal Chemistry \u2013 University of Porto Porto Portugal"},{"name":"Departamento de Ci\u00eancias Qu\u00edmicas Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica Faculdade de Farm\u00e1cia Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Correia\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"CEQUIMED\u2010UP Centre of Medicinal Chemistry \u2013 University of Porto Porto Portugal"},{"name":"Departamento de Ci\u00eancias Qu\u00edmicas Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica Faculdade de Farm\u00e1cia Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S. 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