{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:17:08Z","timestamp":1770740228230,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T00:00:00Z","timestamp":1366761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>New imines, derived from aromatic aldehyde, chalcones and 5\u2010amino\u20101,3,4\u2010thiadiazole\u20102\u2010thiol exhibited promising anti\u2010convulsant activity which is explained through chemo\u2010biological interactions at receptor site producing the inhibition of human <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>arbonic <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nhydrase\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> enzyme (h<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010II) through the proposed pharmacophore model at molecular levels as basis for pharmacological activity. The compounds 5\u2010{1\u2010(4\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hlorophenyl)\u20103\u2010[4\u2010(methoxy\u2010phenyl)\u2010prop\u20102\u2010en\u20101\u2010ylidene]amino}\u20101,3,4\u2010thiadiazole\u20102\u2010thiol (<jats:bold>2b<\/jats:bold>), 5\u2010{[1\u2010(4\u2010chloro\u2010phenyl)]\u20103\u2010[4\u2010(dimethyl\u2010amino\u2010phenyl)\u2010prop\u20102\u2010en\u20101\u2010ylidene]amino}\u20101,3,4\u2010thiadiazole\u20102\u2010thiol (<jats:bold>2c<\/jats:bold>) and 5\u2010{[1\u2010(4\u2010chloro\u2010phenyl)]\u20103\u2010[(4\u2010amino\u2010phenyl)\u2010prop\u20102\u2010en\u20101\u2010ylidene]amino}\u20101,3,4\u2010thiadiazole\u20102\u2010thiol (<jats:bold>2f<\/jats:bold>) showed 100% activity in comparison with standard <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>cetazolamide, a known anti\u2010convulsant drug. The compounds <jats:bold>2c<\/jats:bold>,<jats:bold> 2f<\/jats:bold> also passed the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>otarod and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>thanol <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>otentiation tests which further confirmed them to be safe in motor coordination activity and safe from generating neurological toxicity.<\/jats:p>","DOI":"10.1111\/cbdd.12113","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T09:23:13Z","timestamp":1359537793000},"page":"666-673","source":"Crossref","is-referenced-by-count":12,"title":["An Interactive Human Carbonic Anhydrase\u2010<scp>II<\/scp> (h<scp>CA<\/scp>\u2010<scp>II<\/scp>) Receptor \u2013 Pharmacophore Molecular Model &amp; Anti\u2010Convulsant Activity of the Designed and Synthesized 5\u2010Amino\u20101,3,4\u2010Thiadiazole\u20102\u2010Thiol Conjugated Imine Derivatives"],"prefix":"10.1111","volume":"81","author":[{"given":"Mohammad","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry College of Pharmacy Qassim University Qassim 51452 Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riaz A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry College of Pharmacy Qassim University Qassim 51452 Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Khan","sequence":"additional","affiliation":[{"name":"Buraydah Colleges Buraydah Qassim Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Hamdard University New Delhi 110 062 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.07.056"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568016043477305"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1978.tb04507.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm001027w"},{"key":"e_1_2_6_7_1","volume-title":"Recent Potential Targets for Drug Development","author":"Supuran C.T.","year":"2002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.68.1.33"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00388a038"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00161a025"},{"key":"e_1_2_6_11_1","volume-title":"Comprehensive Practical Organic Chemistry: Preparation and, Quantitative Analysis","author":"Ahuwalia V.K.","year":"2004"},{"key":"e_1_2_6_12_1","volume-title":"Vogel's Textbook of Practical Organic Chemistry","author":"Addison Wesley Logan Ltd","year":"1989"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/jr9580001508"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:24:01Z","timestamp":1697415841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,24]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/cbdd.12113"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12113","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,24]]}}}