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Several analogs comparable in activity to the drug praziquantel have been identified based on <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo japonuicum<\/jats:italic> schistosomes worm viability assay. Structure and activity relationship of these praziquantel aromatic ring\u2010modified compounds was revealed. Specifically, a compound in which a bromine has been introduced in the aromatic ring of praziquantel demonstrated close antischistosomal activity to praziquantel <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/cbdd.12153","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T14:40:41Z","timestamp":1366900841000},"page":"216-225","source":"Crossref","is-referenced-by-count":20,"title":["Praziquantel Derivatives with Antischistosomal Activity: Aromatic Ring Modification"],"prefix":"10.1111","volume":"82","author":[{"given":"Zhi\u2010xia","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science Soochow University 199 RenAi Road Suzhou 215123 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010lei","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Soochow University 199 RenAi Road Suzhou 215123 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Qiao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Soochow University 199 RenAi Road Suzhou 215123 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328318978f"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(95)00026-7"},{"key":"e_1_2_7_4_1","unstructured":"SeubertJ. 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