{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:35:52Z","timestamp":1791549352838,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    A series of twenty piperazine\u2010tethered 7\u2010chloroquinoline\u2013isatin hybrids have been synthesized\n                    <jats:italic>via<\/jats:italic>\n                    either direct nucleophilic substitution or Cu(\n                    <jats:italic>\u0399<\/jats:italic>\n                    )Cl\u2010mediated Mannich reaction. These new conjugates were evaluated for their antimalarial and antitubercular efficacy against a chloroquine\u2010resistant strain of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    and\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    , respectively, while the cytotoxic profiles were evaluated against 3T6 cell line, a permanent mouse embryonic fibroblast cell line. The most potent of the test compound with\n                    <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\n                    <jats:sub>50<\/jats:sub>\n                    of 0.22\u00a0\n                    <jats:italic>\u03bc<\/jats:italic>\n                    <jats:sc>m<\/jats:sc>\n                    against W2 strain of\n                    <jats:italic>P.\u00a0falciparum<\/jats:italic>\n                    and 31.62\u00a0\n                    <jats:italic>\u03bc<\/jats:italic>\n                    <jats:sc>m<\/jats:sc>\n                    against the embryonic fibroblast cell line (cytotoxicity) displayed a high selective index of 143.73.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.12273","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T12:06:33Z","timestamp":1387195593000},"page":"622-629","source":"Crossref","is-referenced-by-count":67,"title":["7\u2010Chloroquinoline\u2013isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation"],"prefix":"10.1111","volume":"83","author":[{"given":"Raghu","family":"Raj","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Nanak Dev University Amritsar Punjab 143005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Biot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle Universit\u00e9 Lille 1 F\u201059650 Villeneuve d'Ascq France"},{"name":"CNRS UMR 8576 Villeneuve d'Ascq F\u201059650 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Carr\u00e8re\u2010Kremer","sequence":"additional","affiliation":[{"name":"Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques UMR 5235 CNRS Universit\u00e9 Montpellier 2 Place Eug\u00e8ne Bataillon 34095 Montpellier Cedex 05 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