{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:38:36Z","timestamp":1788341916234,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>A series of novel 4\u2010aminoquinolinyl and 9\u2010anilinoacridinyl Schiff base hydrazones have been synthesized and evaluated for their antimalarial activity. All compounds were evaluated <jats:italic>in vitro<\/jats:italic> for their antimalarial activity against chloroquine\u2010sensitive strain 3D7 and the chloroquine\u2010resistant <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>1 strain of <jats:italic>Plasmodium falciparum<\/jats:italic> and for cytotoxicity toward Vero cells. Compounds <jats:bold>17<\/jats:bold>,<jats:bold> 20<\/jats:bold>, and <jats:bold>21<\/jats:bold> displayed good activity against the 3D7 strain with IC<jats:sub>50<\/jats:sub> values ranging from 19.69 to 25.38\u00a0n<jats:sc>m<\/jats:sc>. Moreover, compounds <jats:bold>16<\/jats:bold>,<jats:bold> 17<\/jats:bold>,<jats:bold> 21<\/jats:bold>,<jats:bold> 24<\/jats:bold>,<jats:bold> 32,<\/jats:bold> and <jats:bold>33<\/jats:bold> exhibited excellent activities (21.64\u201354.26\u00a0n<jats:sc>m<\/jats:sc>) against K1 strain and several compounds displayed <jats:italic>\u03b2<\/jats:italic>\u2010hematin inhibitory activity, suggesting that they act on the heme crystallization process such as CQ. Compounds were also found to be non\u2010toxic with good selectivity index.<\/jats:p>","DOI":"10.1111\/cbdd.12289","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T13:47:52Z","timestamp":1390225672000},"page":"175-181","source":"Crossref","is-referenced-by-count":41,"title":["Design and Synthesis of a New Class of 4\u2010Aminoquinolinyl\u2010 and 9\u2010Anilinoacridinyl Schiff Base Hydrazones as Potent Antimalarial Agents"],"prefix":"10.1111","volume":"84","author":[{"given":"Moni","family":"Sharma","sequence":"first","affiliation":[{"name":"Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Parasitology CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv V.","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Biochemistry CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Parasitology CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra K.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Division of Biochemistry CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Parasitology CSIR\u2010Central Drug Research Institute Lucknow 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem M. 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