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Although many human non\u2010pancreatic secretory phospholipase A<jats:sub>2<\/jats:sub>inhibitors were reported, few entered into the drug development stage due to various problems. In this study, we discovered seven novel human non\u2010pancreatic secretory phospholipase A<jats:sub>2<\/jats:sub>inhibitors using virtual screen. Of the 99 compounds tested by continuous fluorescence assay, seven are potent human non\u2010pancreatic secretory phospholipase A<jats:sub>2<\/jats:sub>inhibitors with micromolar<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub>values. Typical molecules include 9\u2010fluorenylmethoxycarbonyl protected \u03b1\u2010phenylalanine derivatives and azo compounds, which may serve as novel scaffold for developing potent human non\u2010pancreatic secretory phospholipase A<jats:sub>2<\/jats:sub>inhibitors. These compounds bind to human non\u2010pancreatic secretory phospholipase A<jats:sub>2<\/jats:sub>by interacting with the catalytic calcium ion and the hydrophobic regions in the substrate\u2010binding pocket.<\/jats:p>","DOI":"10.1111\/cbdd.12307","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T06:14:39Z","timestamp":1393395279000},"page":"216-222","source":"Crossref","is-referenced-by-count":3,"title":["Discovery of Novel Secretory Phospholipase A<sub>2<\/sub>Inhibitors Using Virtual Screen"],"prefix":"10.1111","volume":"84","author":[{"given":"Shunchen","family":"Qiu","sequence":"first","affiliation":[{"name":"BNLMS State Key Laboratory of Structural Chemistry for Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Quantitative Biology 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