{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:08:45Z","timestamp":1792548525211,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundations for Research of the State of Rio de Janeiro"},{"name":"State of Minas Gerais"},{"name":"Technological Development Program on Products for Health of Fiocruz"},{"name":"CNPq-MCT\/MS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Malaria is one of the most prevalent parasitic diseases in the world. The global importance of this disease, current vector control limitations, and the absence of an effective vaccine make the use of therapeutic antimalarial drugs the main strategy to control malaria. Chloroquine is a cost\u2010effective antimalarial drug with a relatively robust safety profile, or therapeutic index. However, chloroquine is no longer used alone to treat patients with <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>lasmodium falciparum<\/jats:italic> due to the emergence and spread of chloroquine\u2010resistant strains, which have also been reported for <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>lasmodium vivax<\/jats:italic>. However, the activity of 1,2,3\u2010triazole derivatives against chloroquine\u2010sensitive and chloroquine\u2010resistant strains of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> has been reported in the literature. To enhance the anti\u2010<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> activity of quinoline derivatives, we synthesized 11 new quinoline\u20101<jats:italic>H<\/jats:italic>\u20101,2,3\u2010triazole hybrids with different substituents in the 4\u2010positions of the 1<jats:italic>H<\/jats:italic>\u20101,2,3\u2010triazole ring, which were assayed against the W2\u2010chloroquine\u2010resistant <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> clone. Six compounds exhibited activity against the <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> W2 clone, chloroquine\u2010resistant, with <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> values ranging from 1.4 to 46\u00a0<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>. None of these compounds was toxic to a normal monkey kidney cell line, thus exhibiting good selectivity indexes, as high 351 for one compound (<jats:bold>11<\/jats:bold>).<\/jats:p>","DOI":"10.1111\/cbdd.12321","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T14:35:01Z","timestamp":1399386901000},"page":"325-332","source":"Crossref","is-referenced-by-count":84,"title":["New Compounds Hybrids 1<i>H<\/i>\u20101,2,3\u2010Triazole\u2010Quinoline Against <i>Plasmodium falciparum<\/i>"],"prefix":"10.1111","volume":"84","author":[{"given":"N\u00fabia","family":"Boechat","sequence":"first","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos Instituto de Tecnologia em F\u00e1rmacos \u2013 Farmanguinhos FIOCRUZ Rua Sizenando Nabuco 100 Manguinhos Rio de Janeiro RJ 21041\u2010250 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Lourdes G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos Instituto de Tecnologia em F\u00e1rmacos \u2013 Farmanguinhos FIOCRUZ Rua Sizenando Nabuco 100 Manguinhos Rio de Janeiro RJ 21041\u2010250 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz C. S.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos Instituto de Tecnologia em F\u00e1rmacos \u2013 Farmanguinhos FIOCRUZ Rua Sizenando Nabuco 100 Manguinhos Rio de Janeiro RJ 21041\u2010250 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio M. L.","family":"Jesus","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos Instituto de Tecnologia em F\u00e1rmacos \u2013 Farmanguinhos FIOCRUZ Rua Sizenando Nabuco 100 Manguinhos Rio de Janeiro RJ 21041\u2010250 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene M. M.","family":"Leite","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos Instituto de Tecnologia em F\u00e1rmacos \u2013 Farmanguinhos FIOCRUZ Rua Sizenando Nabuco 100 Manguinhos Rio de Janeiro RJ 21041\u2010250 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos C. S.","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos Instituto de Tecnologia em F\u00e1rmacos \u2013 Farmanguinhos FIOCRUZ Rua Sizenando Nabuco 100 Manguinhos Rio de Janeiro RJ 21041\u2010250 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C. C.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Mal\u00e1ria Centro de Pesquisas Ren\u00e9 Rachou FIOCRUZ Belo Horizonte MG 31090\u2010002 Brazil"},{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Molecular Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte MG 30000\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel M.","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Mal\u00e1ria Centro de Pesquisas Ren\u00e9 Rachou FIOCRUZ Belo Horizonte MG 31090\u2010002 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniana U.","family":"Krettli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Mal\u00e1ria Centro de Pesquisas Ren\u00e9 Rachou FIOCRUZ Belo Horizonte MG 31090\u2010002 Brazil"},{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Medicina Molecular Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte MG 30000\u2010000 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.09.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66420-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4075-4083.2004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-226"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711794927748"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.04.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.10.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.06.038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.04.054"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00510-08"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.10.042"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.05.119"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901178d"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2003624"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.02.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90053-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/3280287"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4894(03)00051-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.12.069"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(86)90368-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00005-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.06.071"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm051118z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2007.06.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5"}],"container-title":["Chemical Biology &amp; 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